ADENOSINE-A1-RECEPTOR GENE STRUCTURE AND REGULATION IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS

被引：4

作者：

UNGERER, M ^{[1
]}

OBERMAIERSKROBRANEK, B ^{[1
]}

LOHSE, MJ ^{[1
]}

机构：

[1] UNIV MUNICH,MAX PLANCK INST BIOCHEM,MOLEK BIOL LAB,AM KLOPFERSPITZ,W-8033 MARTINSFRIED,GERMANY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 226卷 / 04期

关键词：

ADENOSINE-A1; RECEPTORS; POLYMERASE CHAIN REACTION; SPONTANEOUSLY HYPERTENSIVE RAT (SHR);

D O I：

10.1016/0922-4106(92)90058-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In spontaneously hypertensive rats (SHR), both the response to adenosine and the affinity of adenosine A1 receptors (A1R) are altered. We compared the coding sequences and the mRNA expression levels of A1R in SHR and normotensive Wistar rats (NWTR). Neither the nucleotide sequence nor the mRNA level of A1R are altered in SHR, so that gene mutations or an altered gene regulation of A1R cannot account for alterations in A1R function in SHR

引用

页码：381 / 382

页数：2

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