BIPHASIC EFFECT ON NOCICEPTION AND ANTIOPIATE ACTIVITY OF THE NEUROPEPTIDE FF (FLFQPQRFAMIDE) IN THE RAT

被引：75

作者：

OBERLING, P ^{[1
]}

STINUS, L ^{[1
]}

LEMOAL, M ^{[1
]}

SIMONNET, G ^{[1
]}

机构：

[1] CTR NEUROCHIM,CNRS,U419,F-67084 STRASBOURG,FRANCE

来源：

PEPTIDES | 1993年 / 14卷 / 05期

关键词：

NPFF; MORPHINE; HYPERESTHESIA; ANTIOPIATE ACTIVITY; ANALGESIA; TAIL-FLICK TEST;

D O I：

10.1016/0196-9781(93)90067-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of the present study was to systematically investigate the effects of the mammalian neuropeptide Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF) on nociception, using the tail-flick test. We report that ICV administration of NPFF induces a rapid and short-lasting hyperesthesic effect during day or night, for doses ranging from 10 ng to 10 mug. During the night, this hyperesthesic effect is followed by a long-lasting analgesic effect, the magnitude of which is related to the magnitude of the hyperesthesic effect. In addition to this intrinsic effect of NPFF, we report that NPFF reverses morphine-induced analgesia and that the magnitude of the response elicited by NPFF increases as a function of morphine-induced analgesia.

引用

页码：919 / 924

页数：6

共 27 条

[1] CHARACTERIZATION AND LOCALIZATION OF A PUTATIVE MORPHINE-MODULATING PEPTIDE, FLFQPQRFAMIDE, IN THE RAT SPINAL-CORD - BIOCHEMICAL AND IMMUNOCYTOCHEMICAL STUDIES [J].