CYCLODEXTRINS - FIELDS OF APPLICATION. PART II

被引：3

作者：

Duca, Gheorghe ^{[1
]}

Ivancic, Albert ^{[2
]}

Boldescu, Veaceslav ^{[3
]}

机构：

[1] Moldavian Acad Sci, Stefan Cel Mare 1, Kishinev, Moldova

[2] State Univ Moldova, Dept Ind & Ecol Chem, MD-2009 Kishinev, Moldova

[3] State Univ Moldova, Dept Ind & Ecol Chem, MD-2009 Kishinev, Moldova

来源：

CHEMISTRY JOURNAL OF MOLDOVA | 2012年 / 7卷 / 02期

关键词：

cyclodextrins; pharmaceuticals; medicine; inclusion complexes;

D O I：

10.19261/cjm.2012.07(2).15

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper represents an analysis of potential and current applications of cyclodextrins as biologically active substances in medicine. The main applications described here include use of cyclodextrins as agents that form inclusion complexes with endogenous substances (membrane lipids, cellular cholesterol), agents that form inclusion complexes with exogenous substances with their man role as guest molecules (sugammadex, FBCx), agents that block endogenous and exogenous macromolecules (ion channels, anthrax toxin, alpha-hemolysin), and agents which activity is based on the chemical nature of them and of their derivatives (cyclodextrin polysulphate derivatives). The first classification for medically important biological activity of cyclodextrins has been proposed.

引用

页码：39 / 45

页数：7

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