RECEPTOR-BINDING SITE-DELETED FOOT-AND-MOUTH-DISEASE (FMD) VIRUS PROTECTS CATTLE FROM FMD

被引：68

作者：

MCKENNA, TSC ^{[1
]}

LUBROTH, J ^{[1
]}

RIEDER, E ^{[1
]}

BAXT, B ^{[1
]}

MASON, PW ^{[1
]}

机构：

[1] USDA ARS,PLUM ISL ANIM DIS CTR,GREENPORT,NY 11944

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 09期

关键词：

D O I：

10.1128/JVI.69.9.5787-5790.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Binding of foot-and-mouth disease virus (FMDV) to cells requires an arginine-glycine-aspartic acid (RGD) sequence in the capsid protein VP1. We have genetically engineered an FMDV in which these three amino acids have been deleted, producing a virus particle which is unable to bind to cells. Cattle vaccinated with these receptor binding site-deleted virions were protected from disease when challenged with a virulent virus, demonstrating that these RGD deleted viruses could serve as the basis for fool-and-mouth disease vaccines safer than those currently in use. This strategy may prove useful in the development of vaccines for other viral diseases.

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页码：5787 / 5790

页数：4

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