ANALYSIS OF CD14+ CELLS AND CD56+ CELLS IN URINE USING FLOW-CYTOMETRY - A USEFUL TOOL FOR MONITORING DISEASE-ACTIVITY OF IGA NEPHROPATHY

被引:0
作者
HOTTA, O [1 ]
TAGUMA, Y [1 ]
OOYAMA, M [1 ]
YUSA, N [1 ]
NAGURA, H [1 ]
机构
[1] TOHOKU UNIV MED,DEPT PATHOL,AOBA KU,SENDAI,JAPAN
关键词
FLOW CYTOMETRY; CELLULAR CRESCENT; MACROPHAGE; NK CELL; IGA NEPHROPATHY;
D O I
暂无
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The interrelationship between glomerular inflammatory activity and urinary leukocytes was investigated in IgA nephropathy (IgAN). The numbers of T cells, macrophages, and natural killer (NK) cells in urine were evaluated using flow cytometry. The glomerular changes were studied by routine histopathological methods and by immunohistochemical methods using monoclonal antibodies. Biopsies were classified into three categories: non-crescentic IgAN (n = 44), inactive-crescentic IgAN (n = 17), and active-crescentic IgAN (n = 18). Macrophages (Leu M3/CD14) and NK cells (Leu 19/CD56) were predominantly present within active crescents, whereas T cells (Leu 4/CD3) were less frequently observed. A significant increase of mononuclear cells in urine was observed in patients with active-crescentic IgAN as compared with other groups. Moreover, the extent of active crescents in biopsies was significantly correlated with the number of CD14+ cells and CD56+ cells in urine (CD14: r = 0.6858, p <0.01; CD56: r = 0.6373, p <0.01). These findings suggest that analysis of CD14+ cells and CD56+ cells in urine using flow cytometry can be a useful tool for monitoring disease activity of IgAN.
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页码:289 / 294
页数:6
相关论文
共 22 条
  • [1] ABE T, 1986, CLIN NEPHROL, V25, P37
  • [2] CRESCENTIC IGA NEPHROPATHY
    ABUELO, JG
    ESPARZA, AR
    MATARESE, RA
    ENDRENY, RG
    CARVALHO, JS
    ALLEGRA, SR
    [J]. MEDICINE, 1984, 63 (06) : 396 - 406
  • [3] ALAMARTINE E, 1990, TRANSPLANTATION, V50, P569
  • [4] SIGNIFICANCE OF MONONUCLEAR PHAGOCYTES IN IGA NEPHROPATHY
    ARIMA, S
    NAKAYAMA, M
    NAITO, M
    SATO, T
    TAKAHASHI, K
    [J]. KIDNEY INTERNATIONAL, 1991, 39 (04) : 684 - 692
  • [5] CLARKSON AR, 1977, CLIN NEPHROL, V8, P459
  • [6] THE IMPORTANCE OF SAMPLE-SIZE IN THE INTERPRETATION OF THE RENAL BIOPSY
    CORWIN, HL
    SCHWARTZ, MM
    LEWIS, EJ
    [J]. AMERICAN JOURNAL OF NEPHROLOGY, 1988, 8 (02) : 85 - 89
  • [7] DAMICO G, 1987, Q J MED, V245, P707
  • [8] CELLULAR COMPOSITION OF CRESCENTS IN HUMAN RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS IDENTIFIED USING MONOCLONAL-ANTIBODIES
    HANCOCK, WW
    ATKINS, RC
    [J]. AMERICAN JOURNAL OF NEPHROLOGY, 1984, 4 (03) : 177 - 181
  • [9] CD16+ AND CD56+ CELLS AS MARKERS OF NECROTIZING AND CRESCENTIC GLOMERULONEPHRITIS AND ACTIVE IGA GLOMERULONEPHROPATHY
    HOTTA, O
    SEKI, S
    TAGUMA, Y
    SHIMODA, A
    ABO, T
    TAKAHASHI, H
    [J]. NEPHRON, 1991, 57 (02): : 239 - 240
  • [10] POLYMORPHS INFILTRATE GLOMERULI IN MESANGIAL IGA GLOMERULONEPHRITIS
    KINCAIDSMITH, P
    NICHOLLS, K
    BIRCHALL, I
    [J]. KIDNEY INTERNATIONAL, 1989, 36 (06) : 1108 - 1111