SERIAL THROMBOLYSIS-RELATED CHANGES AFTER THROMBOLYTIC THERAPY WITH TPA IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION

被引:22
作者
HO, CH
WANG, SP
机构
[1] Division of Hematology, Department of Internal Medicine, Veterans General Hospital, Taipei
[2] Division of Cardiology, Department of Internal Medicine, Veterans General Hospital, Taipei
关键词
acute myocardial infarction; thrombolysis-related changes; Thrombolytic therapy; tissue-type plasminogen activator infusion;
D O I
10.1016/0049-3848(90)90102-I
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Twenty-nine patients with acute myocardial infarction were given recombinant tissue plasminogen activator (tPA) within 6 hr after onset of chest pain (mean: 3.2 hr ) with a total dose of 100mg iv drip given within 3hr for thrombolytic therapy. Serial determinations of total FDP, FDP D-Dimer (specific for FbDP), fibrinogen (Fg), PT, APTT, reptilase time (RT), plasminogen, alpha2-antiplasmin (AAP), euglobulin lysis time (ELT) and antithrombin III (ATIII) were performed before and 1, 2, 4, 6, 12, 24, 48 hr after initiation of tPA injection in the 29 patients in order to evaluate the hemostatic changes after thrombolytic therapy. Decreases of plasminogen,Fg,AAP & ELT were found from 1 hr after therapy and persisted to 24,12,24 & 12 hr, respectively, with the maximum decrease usually between 1-4 hr. Increases of FDP, FDP D-dimer, PT, APTT & RT were found from 1, 1, 2, 1 & 1 hr after therapy, respectively, and sustained to 24, 12, 12, 24 & 12 hr, respectively, with maximum increases between 1-4 hr. No significant changes of ATIII were noted during the 48-hr study-period. 4 of these 29 patients (13.79%) had the complication of localized bleeding, 1 of them needed 1 unit of packed red blood cell transfusion. All thrombolysis-related changes recovered within 24 hr after tPA therapy. No parameter we have studied so far could be used for the prediction of the possibility of coronary patency after tPA therapy. But markedly elevated FDP was found to be associated with high risk of bleeding complication. As the coagulation changes persist for 24 hr or longer, careful monitoring of the coagulation tests and close observation of clinical bleeding signs up to 48 hr are necessary in patients treated with tPA. © 1990.
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页码:331 / 341
页数:11
相关论文
共 23 条
[1]  
CLAUSS A, 1957, ACTA HAEMATOL-BASEL, V17, P37
[2]   ANALYSIS OF COAGULATION AND FIBRINOLYSIS DURING INTRAVENOUS-INFUSION OF RECOMBINANT HUMAN TISSUE-TYPE PLASMINOGEN-ACTIVATOR IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION [J].
COLLEN, D ;
BOUNAMEAUX, H ;
DECOCK, F ;
LIJNEN, HR ;
VERSTRAETE, M .
CIRCULATION, 1986, 73 (03) :511-517
[3]   CORONARY THROMBOLYSIS WITH RECOMBINANT HUMAN TISSUE-TYPE PLASMINOGEN-ACTIVATOR - A PROSPECTIVE, RANDOMIZED, PLACEBO-CONTROLLED TRIAL [J].
COLLEN, D ;
TOPOL, EJ ;
TIEFENBRUNN, AJ ;
GOLD, HK ;
WEISFELDT, ML ;
SOBEL, BE ;
LEINBACH, RC ;
BRINKER, JA ;
LUDBROOK, PA ;
YASUDA, I ;
BULKLEY, BH ;
ROBISON, AK ;
HUTTER, AM ;
BELL, WR ;
SPADARO, JJ ;
KHAW, BA ;
GROSSBARD, EB .
CIRCULATION, 1984, 70 (06) :1012-1017
[4]  
COLLEN D, 1984, J PHARMACOL EXP THER, V231, P146
[5]  
DINGEMAN C, 1982, J BIOL CHEM, V257, P2920
[6]   CORONARY THROMBOLYSIS AND INFARCT SIZE-REDUCTION AFTER INTRAVENOUS-INFUSION OF RECOMBINANT TISSUE-TYPE PLASMINOGEN-ACTIVATOR IN NONHUMAN-PRIMATES [J].
FLAMENG, W ;
VANDEWERF, F ;
VANHAECKE, J ;
VERSTRAETE, M ;
COLLEN, D .
JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (01) :84-90
[7]   STUDIES ON PLASMA ANTI-PLASMIN ACTIVITY USING A NEW PLASMIN SPECIFIC CHROMOGENIC TRIPEPTIDE SUBSTRATE [J].
GALLIMORE, MJ ;
AMUNDSEN, E ;
AASEN, AO ;
LARSBRAATEN, M ;
LYNGAAS, K ;
SVENDSEN, L .
THROMBOSIS RESEARCH, 1979, 14 (01) :51-60
[8]   DOSE-DEPENDENT THROMBOLYSIS, PHARMACOKINETICS AND HEMOSTATIC EFFECTS OF RECOMBINANT HUMAN TISSUE-TYPE PLASMINOGEN-ACTIVATOR FOR CORONARY-THROMBOSIS [J].
GARABEDIAN, HD ;
GOLD, HK ;
LEINBACH, RC ;
YASUDA, T ;
JOHNS, JA ;
COLLEN, D .
AMERICAN JOURNAL OF CARDIOLOGY, 1986, 58 (09) :673-679
[9]  
GOLD HK, 1984, CIRCULATION, V70, P700, DOI 10.1161/01.CIR.70.4.700
[10]   THROMBOLYSIS IN MYOCARDIAL-INFARCTION (TIMI) COMPARATIVE-STUDIES OF CORONARY REPERFUSION AND SYSTEMIC FIBRINOGENOLYSIS WITH 2 FORMS OF RECOMBINANT TISSUE-TYPE PLASMINOGEN-ACTIVATOR [J].
MUELLER, HS ;
RAO, AK ;
FORMAN, SA .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1987, 10 (03) :479-490