SPONTANEOUS RESOLUTION OF TRANSFUSION-ASSOCIATED GRAFT-VERSUS-HOST DISEASE

被引：12

作者：

MORI, S

MATSUSHITA, H

OZAKI, K

ISHIDA, A

TOKUHIRA, M

NAKAJIMA, H

KIZAKI, M

SUGIURA, H

KIKUCHI, A

HANDA, M

KAWAI, Y

YAMAMORI, S

IKEDA, Y

机构：

[1] KEIO UNIV,SCH MED,DIV PATHOL,CENT CLIN LABS,TOKYO 160,JAPAN

[2] KEIO UNIV,SCH MED,DEPT DERMATOL,TOKYO 160,JAPAN

[3] MITSUBISHI YUKA CO,TOKYO,JAPAN

[4] KEIO UNIV,SCH MED,CTR TRANSFUS,DEPT LAB MED,DIV PATHOL,TOKYO,JAPAN

来源：

TRANSFUSION | 1995年 / 35卷 / 05期

关键词：

D O I：

10.1046/j.1537-2995.1995.35595259155.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Transfusion-associated graft-versus-host disease (TA-GVHD) is a serious complication of blood transfusion that is characterized by high fever, a scaly maculopapular erythematous rash, diarrhea, hepatocellular damage with marked elevation of liver function test values, and pancytopenia. It can occur in immunocompetent as well as immunocompromised recipients, The existence of atypical TA-GVHD that resolves spontaneously and does not exhibit all of the manifestations has been suggested, but there has been to date no documented diagnosis of GVHD supported by evidence of engraftment. Case Report: A female patient presented and was diagnosed with acute myelogenous leukemia (AML:M4), and, after unsuccessful combination chemotherapy, she received a transfusion and developed manifestation of TA-GVHD as well as evidence of chimerism. TA-GVHD was proved by demonstrating Y chromosome-specific genes in the skin by polymerase chain reaction. The manifestations of clinical GVHD abated within 4 months. Conclusion: Polymerase chain reaction analysis of Y chromosomes in specimens from female patients is useful in the diagnosis of suspected cases of spontaneously resolving TA-GVHD.

引用

页码：431 / 435

页数：5

共 21 条

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