SYNTHESIS OF A BENZYLAMIDINE DERIVED FROM D-MANNOSE - A POTENT MANNOSIDASE INHIBITOR

被引：36

作者：

BLERIOT, Y ^{[1
]}

GENREGRANDPIERRE, A ^{[1
]}

TELLIER, C ^{[1
]}

机构：

[1] FAC SCI TECHN,CNRS,RMN & REACT CHIM LAB,F-44072 NANTES,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(00)73182-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a substituted mannopyranose-based amidine is described and its potential as glycosidase inhibitor evaluated. This new aminosugar derivative acts as a potent glycosidase inhibitor by virtue of its charge and shape similarities to the mannopyranosyl cation. The benzyl group of this pseudodisaccharide may also contribute to enzyme transition-state interactions.

引用

页码：1867 / 1870

页数：4

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