MODIFICATION OF THE INVITRO CYTOTOXICITY OF HYDROGEN-PEROXIDE BY IRON COMPLEXES

被引：18

作者：

JONAS, SK

RILEY, PA

机构：

[1] UNIV COLL & MIDDLESEX SCH MED, DEPT CHEM PATHOL, WINDEYER BLDG, CLEVELAND ST, LONDON W1P 6DB, ENGLAND

[2] BRUNEL UNIV, DEPT BIOL & BIOCHEM, UXBRIDGE UB8 3PH, MIDDX, ENGLAND

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1992年 / 17卷 / 06期

关键词：

CYTOTOXICITY; H2O2; IRON COMPLEXES; INTERNALIZATION; REDUCTION;

D O I：

10.3109/10715769209083145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of a range of iron chelates on the cytotoxicity of H2O2 was studied on a mammalian epithelial cell line. Iron complexes which were internalised enhanced the cytotoxicity of H2O2 measured by delayed thymidine incorporation. Iron complexed to 8-hydroxyquinoline (Fe/8-HQ) potentiated the cytotoxicity of 50 muM by 38% and Fe/dextran by 23%. Pre-exposure of cells to Fe/dextran at 4-degrees-C did not result in any potentiation of H2O2-induced cytotoxicity which we ascribe to failure of the Fe/dextran to be endocytosed at low temperature. Iron complexes which are slowly taken up or remain extracellular protected the cells from H2O2-induced cytotoxicity. Thus, Fe/EDTA inhibited the cytotoxicity of 50 muM H2O2 by 33%; Fe/ADP by 80% and Fe/ATP by 88%, suggesting mutual extracellular detoxification.

引用

页码：407 / 419

页数：13

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