THE CHIRAL PURITY OF A TRIAZOLYLKETONE CRYSTALLIZED FROM RACEMIC SOLUTIONS

被引：31
|
作者：
DAVEY, RJ [1 ]
BLACK, SN [1 ]
WILLIAMS, LJ [1 ]
MCEWAN, D [1 ]
SADLER, DE [1 ]
机构：
[1] ICI FINE CHEM MFG ORG,GRANGEMOUTH FK3 8XG,ENGLAND
来源：
JOURNAL OF CRYSTAL GROWTH | 1990年 / 102卷 / 1-2期
关键词：
D O I：
10.1016/0022-0248(90)90890-W
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The triazolyl ketone (I) crystallises from racemic solutions as a racemic mixture (conglomerate) suggesting that crystallisation offers a simple route to the resolution of its R and S isomers. Analysis of single crystals, however, shows that not only are they rarely chirally pure but also they are highly strained and defective. These phenomena suggest that the stereoselectivity of the growing crystal surface is poor allowing the structure to switch randomly from the R to S isomer. © 1990.
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页码：97 / 102
页数：6
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