7-CHLOROKYNURENIC ACID, A STRYCHNINE-INSENSITIVE GLYCINE RECEPTOR ANTAGONIST, INHIBITS LIMBIC SEIZURE KINDLING

被引：34
作者：
CROUCHER, MJ
BRADFORD, HF
机构：
[1] Department of Biochemistry, Imperial College of Science, Technology and Medicine, London
来源：
NEUROSCIENCE LETTERS | 1990年 / 118卷 / 01期
基金：
英国医学研究理事会;
关键词：
7-Chlorokynurenic acid; Amygdala; Anticonvulsant; Epilepsy; Kindling; Seizures; Strychnine-insensitive glycine receptors;
D O I：
10.1016/0304-3940(90)90241-Z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Electrical kindling of the rat amygdala was performed following daily intra-amygdaloid injections of the strychnine-insensitive glycine receptor antagonist 7-chlorokynurenic acid (7-C1KYN) (10 nmol), 7-C1KYN (10 nmol) plus glycine (40 nmol), or vehicle alone. Control (vehicle-treated) animals showed their first fully kindled (Stage 5) seizure after 9.5±0.8 daily stimulations. Animals pretreated with 7-C1KYN (10 nmol) showed a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response. This inhibitory influence of 7-C1KYN was blocked when glycine (40 nmol) was co-injected daily with the antagonist. The mean initial afterdischarge threshold (ADT) was unaffected by pretreatment with 7-C1KYN (10 nmol). These results provide the first demonstration of an antiepileptogenic action of a strychnine-insensitive glycine receptor antagonist. They further support a key involvement of NMDA receptors in generative mechanisms of epilepsy. © 1990.
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页码：29 / 32
页数：4
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