SUPPRESSION OF NIGROSTRIATAL AND MESOLIMBIC DOPAMINE RELEASE INVIVO FOLLOWING NORADRENALINE DEPLETION BY DSP-4 - A MICRODIALYSIS STUDY

被引：77

作者：

LATEGAN, AJ ^{[1
]}

MARIEN, MR ^{[1
]}

COLPAERT, FC ^{[1
]}

机构：

[1] FONDAX GRP RECH SERVIER, DIV NEUROBIOL P10, F-92800 PUTEAUX, FRANCE

来源：

LIFE SCIENCES | 1992年 / 50卷 / 14期

关键词：

D O I：

10.1016/0024-3205(92)90093-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pretreatment of rats with the noradrenergic neurotoxin DSP-4 selectively reduced regional levels of noradrenaline in the brain by more than 75%, and decreased the concentration of endogenous DA in microdialysates of the caudate nucleus and nucleus accumbens by 52% and 28%, respectively. Results support the hypothesis that central noradrenergic mechanisms facilitate nigrostriatal and mesolimbic dopamine transmission in vivo.

引用

页码：995 / 999

页数：5

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