Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis

被引：83
作者：
Sata, Masataka [1 ]
Fukuda, Daiju
机构：
[1] Univ Tokushima, Inst Hlth Biosci, Grad Sch, Dept Cardiovasc Med, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan
来源：
JOURNAL OF MEDICAL INVESTIGATION | 2010年 / 57卷 / 1-2期
关键词：
atherosclerosis; renin-angiotensin system; reactive oxygen species; inflammation;
D O I：
10.2152/jmi.57.12
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the initiation and progression of atherosclerosis, thereby contributing to development of cardiovascular diseases. Angiotensin II (Ang II), a major substrate in RAS, stimulates atherosclerosis through various deleterious effects such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic actions of Ang II are mediated by reactive oxygen species (ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy.
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收藏
页码：12 / 25
页数：14
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