THE FREQUENCY OF MICRONUCLEI IN BONE-MARROW ERYTHROBLASTS DURING THE TREATMENT OF CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：2
|
作者：
SLAVOTINEK, A
THOMSON, A
EYNAUD, P
PERRY, P
STEEL, CM
EDEN, OB
机构：
[1] ROYAL HOSP SICK CHILDREN,EDINBURGH EH9 1LF,MIDLOTHIAN,SCOTLAND
[2] ST BARTHOLOMEWS HOSP,DEPT PAEDIAT ONCOL,LONDON EC1A 7BE,ENGLAND
来源：
MUTATION RESEARCH | 1993年 / 303卷 / 01期
关键词：
MICRONUCLEI; CHILDHOOD ALL; CHEMOTHERAPY; LEUKEMIA; CHILDHOOD; ACUTE;
D O I：
10.1016/0165-7992(93)90003-E
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We scored the frequency of micronuclei in bone-marrow erythroblasts from 41 patients with childhood acute lymphoblastic leukaemia (childhood ALL) at diagnosis and during their 2-year treatment cycle in order to see whether there would be any variation in the cytogenetic damage induced by chemotherapy. We found that most patients showed the same trend in micronucleus frequency, with a progressive rise from the diagnostic slide through induction to pre-intensification and completion of treatment. The rise was attributed to damage to the erythroblasts occurring as a result of chemotherapy, and was judged not prognostically significant in this study.
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收藏
页码：11 / 18
页数：8
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