SERUM-LIPOPROTEIN PROFILE IN THE MEDITERRANEAN VARIANT OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY

被引：25

作者：

MUNTONI, S

BATETTA, B

DESSI, S

MUNTONI, S

PANI, P

机构：

[1] Centro Regionale per le Malattie Dismetaboliche e l'Arteriosclerosi, Ospedale 'G. Brotzu' (S. Michele), Cagliari, 09123

[2] Istituto di Farmacologia e Patologia Biochimica, Università di Cagliari - Cagliari

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1992年 / 8卷

关键词：

APO-B; CHOLESTEROL; G-6-PD DEFICIENCY; LDL-CHOLESTEROL;

D O I：

10.1007/BF00145349

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Sardinian males with erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency have lower serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB), compared to normals. Since the enzyme deficiency is expressed also in nucleated cells, we studied cholesterol (C) and DNA synthesis and LDL-receptor expression in freshly isolated circulating mononuclear cells from normal and G-6-PD-deficient Sardinians. Synthesis of C (as C-14-acetate incorporation) and of DNA (as H-3-thymidine incorporation) was clearly reduced, both in basal state and after PHA stimulation, in G-6-PD-deficient cells compared to normal cells. On the other hand, no clear influence of G-6-PD deficiency on LDL-receptor expression could be demonstrated. The Mediterranean variant of G-6-PD deficiency is characterized, whatever the metabolic mechanism may be, by a serum lipoprotein pattern of reduced atherogenicity.

引用

页码：48 / 53

页数：6

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