EFFECTS OF CALCIUM AND POTASSIUM EXTRACELLULAR IONIC CONCENTRATION CHANGES ON THE HIPPOCAMPAL CA1 ACTIVITY OF PURINERGIC DRUGS

被引：1

作者：

FRANK, C ^{[1
]}

SAGRATELLA, S ^{[1
]}

DECAROLIS, AS ^{[1
]}

机构：

[1] IST SUPER SANITA,DEPT PHARMACOL,VIALE REGINA ELENA 299,I-00161 ROME,ITALY

来源：

GENERAL PHARMACOLOGY | 1991年 / 22卷 / 02期

关键词：

D O I：

10.1016/0306-3623(91)90439-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The influence of the change of potassium and calcium concentrations in the medium bathing hippocampal slices has been tested on the purinergic drug effects. 2. The depressive effects of purinergic agonists were antagonized by 50% by doubling the potassium concentrations, while they were not affected by doubling calcium concentrations. 3. The data demonstrate a direct intrinsic activity of potassium ions, and suggest a possible direct interaction between adenosine receptors and potassium transneuronal fluxes.

引用

页码：237 / 241

页数：5

共 50 条

[1] EFFECTS OF CHANGES IN EXTRACELLULAR POTASSIUM, MAGNESIUM AND CALCIUM-CONCENTRATION ON SYNAPTIC TRANSMISSION IN AREA CA1 AND THE DENTATE GYRUS OF RAT HIPPOCAMPAL SLICES
RAUSCHE, G
IGELMUND, P
HEINEMANN, U
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1990, 415 (05): : 588 - 593
[2] Effects of antiepileptic drugs on extracellular pH regulation in the hippocampal CA1 region in vivo
Aribi, AM
Stringer, JL
EPILEPSY RESEARCH, 2002, 49 (02) : 143 - 151
[3] THE SOURCES OF EXTRACELLULAR POTASSIUM ACCUMULATION IN THE CA1 REGION OF HIPPOCAMPAL SLICES
AITKEN, PG
SOMJEN, GG
BRAIN RESEARCH, 1986, 369 (1-2) : 163 - 167
[4] Evoked presynaptic field potentials in CA1: Effects following transient extracellular calcium concentration changes.
Kuhnt, U
EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 : 21 - 21
[5] SPREADING EPILEPTIFORM ACTIVITY OF CA1 HIPPOCAMPAL-NEURONS IN LOW EXTRACELLULAR CALCIUM SOLUTIONS
YAARI, Y
KONNERTH, A
HEINEMANN, U
ISRAEL JOURNAL OF MEDICAL SCIENCES, 1984, 20 (05): : 463 - 463
[6] SPONTANEOUS EPILEPTIFORM ACTIVITY OF CA1 HIPPOCAMPAL-NEURONS IN LOW EXTRACELLULAR CALCIUM SOLUTIONS
YAARI, Y
KONNERTH, A
HEINEMANN, U
EXPERIMENTAL BRAIN RESEARCH, 1983, 51 (01) : 153 - 156
[7] Effects of barium on stimulus induced changes in extracellular potassium concentration in area CA1 of hippocampal slices from normal and pilocarpine-treated epileptic rats
Gabriel, S
Eilers, A
Kivi, A
Kovacs, R
Schulze, K
Lehmann, TN
Heinemann, U
NEUROSCIENCE LETTERS, 1998, 242 (01) : 9 - 12
[8] Effect of hypoxia on calcium channels depends on extracellular calcium in CA1 hippocampal neurons
Lukyanetz, EA
Shkryl, VM
Kravchuk, OV
Kostyuk, PG
BRAIN RESEARCH, 2003, 980 (01) : 128 - 134
[9] EFFECTS OF SOME CALCIUM-ANTAGONISTS AND OF CALCIUM-CONCENTRATION CHANGES ON CA1 PAIRED PULSE INHIBITION IN RAT HIPPOCAMPAL SLICES
SAGRATELLA, S
PROIETTI, ML
FRANK, C
DECAROLIS, AS
GENERAL PHARMACOLOGY, 1991, 22 (02): : 227 - 230
[10] GABA AND BACLOFEN REDUCE CHANGES IN EXTRACELLULAR FREE CALCIUM IN AREA CA1 OF RAT HIPPOCAMPAL SLICES
HEINEMANN, U
HAMON, B
KONNERTH, A
NEUROSCIENCE LETTERS, 1984, 47 (03) : 295 - 300

← 1 2 3 4 5 →