EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE AND BROMOCRYPTINE (CB-154) IN STATES OF ABNORMAL PITUITARY-ADRENAL-FUNCTION

被引：60

作者：

BENKER, G ^{[1
]}

HACKENBERG, K ^{[1
]}

HAMBURGER, B ^{[1
]}

REINWEIN, D ^{[1
]}

机构：

[1] UNIV ESSEN, MED KLIN & POLIKLIN, DEPT CLIN ENDOCRINOL, HUFELAND STR 55, 43 ESSEN, FED REP GER

来源：

CLINICAL ENDOCRINOLOGY | 1976年 / 5卷 / 02期

关键词：

D O I：

10.1111/j.1365-2265.1976.tb02831.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Growth hormone release-inhibiting hormone (GHR-IH) was administered to 5 patients with abnormal pituitary-adrenal function. There was immediate suppression by about 50% of ACTH levels in 2 patients who had undergone bilateral adrenalectomy because of Cushing''s disease; 1 of them had Nelson''s syndrome. Bromocryptine (2.5 mg) suppressed ACTH levels by 62-67% for more than 6 h in these patients. GHR-IH did not significantly influence cortisol secretion by an adrenal carcinoma and only slight changes were seen in 2 patients with Addison''s disease. The possible therapeutic implications are discussed.

引用

页码：187 / 190

页数：4

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