HOMOLOGS OF ANTI-HIV ACTIVE ISODIDEOXYNUCLEOSIDES

被引：12

作者：

BOLON, P ^{[1
]}

JAHNKE, TS ^{[1
]}

NAIR, V ^{[1
]}

机构：

[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242

来源：

TETRAHEDRON | 1995年 / 51卷 / 38期

基金：

美国国家卫生研究院;

关键词：

ISODIDEOXYNUCLEOSIDES; HOMOLOGS; CONVERGENT SYNTHESIS; ANTI-HIV;

D O I：

10.1016/0040-4020(95)00626-J

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a homologous series of compounds related to the anti-HN active class of compounds known as (S,S)-isodideoxynucleosides has been completed by a convergent route using a modified carbohydrate intermediate. This precursor, synthesized from D-glucose, was coupled with a variety of natural purine and pyrimidine bases to regiospecifically and stereospecifically afford the desired new class of compounds.

引用

页码：10443 / 10452

页数：10

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