NEW TELEOCIDIN-RELATED METABOLITES, (-)-7-GERANYLINDOLACTAM-V AND BLASTMYCETIN-F, FROM STREPTOVERTICILLIUM-BLASTMYCETICUM

被引：7

作者：

IRIE, K

KAJIYAMA, SI

OKUNO, S

KONDO, M

KOSHIMIZU, K

HAYASHI, H

ARAI, M

NISHINO, H

IWASHIMA, A

机构：

[1] UNIV OSAKA PREFECTURE,COLL AGR,DEPT AGR CHEM,SAKAI,OSAKA 593,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIKYO KU,KYOTO 602,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 03期

关键词：

D O I：

10.1021/np50105a005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new teleocidin-related metabolites, (-)-7-geranylindolactam-V [2] and blastmycetin F [3], were isolated from fermentation broths of the actinomycete Streptoverticillium blastmyceticum NA34-17, and their structures were determined by spectroscopic methods. Compound 2 bound strongly to phorbol ester receptors in a mouse epidermal particulate fraction, suggesting that it is a potent in vivo rumor promoter comparable to teleocidins A-1 [4] and B-4 [5].

引用

收藏

页码：363 / 368

页数：6

相关论文

共 32 条

[1] DIRECT MEASUREMENT OF SPECIFIC BINDING OF HIGHLY LIPOPHILIC PHORBOL DIESTER TO MOUSE EPIDERMAL MEMBRANES USING COLD ACETONE [J].

ASHENDEL, CL ;

BOUTWELL, RK .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 99 (02) :543-549

[2] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].

BAX, A ;

SUMMERS, MF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) :2093-2094

[3] SEAWEED DERMATITIS - STRUCTURE OF LYNGBYATOXIN-A [J].

CARDELLINA, JH ;

MARNER, FJ ;

MOORE, RE .

SCIENCE, 1979, 204 (4389) :193-195

[4] SYNTHESIS AND STEREOCHEMISTRY OF INDOLACTAM-V, AN ACTIVE FRAGMENT OF TELEOCIDINS - STRUCTURAL REQUIREMENTS FOR TUMOR-PROMOTING ACTIVITY [J].

ENDO, Y ;

SHUDO, K ;

ITAI, A ;

HASEGAWA, M ;

SAKAI, S .

TETRAHEDRON, 1986, 42 (21) :5905-5924

[5]

FUJIKI H, 1988, CANCER RES, V48, P4211

[6] INDOLE ALKALOIDS - DIHYDROTELEOCIDIN-B, TELEOCIDIN, AND LYNGBYATOXIN-A AS MEMBERS OF A NEW CLASS OF TUMOR PROMOTERS [J].

FUJIKI, H ;

MORI, M ;

NAKAYASU, M ;

TERADA, M ;

SUGIMURA, T ;

MOORE, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06) :3872-3876

[7]

HAGIWARA N, 1988, AGR BIOL CHEM TOKYO, V52, P641

[8] THE METABOLISM OF INDOLE ALKALOID TUMOR PROMOTER, (-)-INDOLACTAM-V, WHICH HAS THE FUNDAMENTAL STRUCTURE OF TELEOCIDINS, BY RAT-LIVER MICROSOMES [J].

HAGIWARA, N ;

IRIE, K ;

TOKUDA, H ;

KOSHIMIZU, K .

CARCINOGENESIS, 1987, 8 (07) :963-965

[9] X-RAY STRUCTURE DETERMINATION OF DIHYDROTELEOCIDIN B MONOBROMOACETATE [J].

HARADA, H ;

SAKABE, N ;

HIRATA, Y .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1966, 39 (08) :1773-+

[10] COLOUR REACTIONS OF HYDROXYSKATOLES [J].

HEACOCK, RA ;

MAHON, ME .

JOURNAL OF CHROMATOGRAPHY, 1965, 17 (02) :338-&

← 1 2 3 4 →