RECOGNITION BY HUMAN V-GAMMA-9/V-DELTA-2 T-CELLS OF A GROEL HOMOLOG ON DAUDI-BURKITT LYMPHOMA-CELLS

被引：384
作者：
FISCH, P
MALKOVSKY, M
KOVATS, S
STURM, E
BRAAKMAN, E
KLEIN, BS
VOSS, SD
MORRISSEY, LW
DEMARS, R
WELCH, WJ
BOLHUIS, RLH
SONDEL, PM
机构：
[1] UNIV WISCONSIN, DEPT HUMAN ONCOL, MADISON, WI 53792 USA
[2] UNIV WISCONSIN, DEPT MED MICROBIOL & IMMUNOL, MADISON, WI 53706 USA
[3] UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53706 USA
[4] UNIV WISCONSIN, GENET LAB, MADISON, WI 53706 USA
[5] UNIV WISCONSIN, DEPT PEDIAT, MADISON, WI 53792 USA
[6] UNIV WISCONSIN, DEPT MED, MADISON, WI 53792 USA
[7] DR DANIEL DENHOED CANC CTR, 3075 EA ROTTERDAM, NETHERLANDS
[8] UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94143 USA
[9] UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA
[10] UNIV WISCONSIN, DEPT GENET, MADISON, WI 53792 USA
来源：
SCIENCE | 1990年 / 250卷 / 4985期
关键词：
D O I：
10.1126/science.1978758
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
All human γδ T cells coexpressing the products of the variable (V) region T cell receptor (TCR) gene segments Vγ9 and V δ2 recognize antigens from some mycobacterial extracts and Daudi cells. Exogenous and endogenous ligands on the cell surface, homologous to the groEL heat shock family, induced reactivities that resembled superantigen responses in this major subset of human peripheral blood γδ T cells. Stimulation of human Vγ9/Vδ2 T cells is not restricted by human leukocyte antigens (HLA), including nonpolymorphic β2-microglobulin (β2M)-associated class Ib molecules. These data may be important for understanding the role of γδ T cells in autoimmunity and in responses to microorganisms and tumors.
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页码：1269 / 1273
页数：5
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