THE INFLUENCE OF ADRENALECTOMY ON ALPHA-ADRENOCEPTOR RESPONSES IN RAT CEREBRAL-CORTEX SLICES

被引：15
作者：
ROBINSON, JP
KENDALL, DA
机构：
[1] Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham
来源：
MOLECULAR BRAIN RESEARCH | 1990年 / 7卷 / 01期
关键词：
Adrenalectomy; Cyclic adenosine monophosphate; Metopirone; Phorbol ester; α[!sub]1[!/sub]-Adrenoceptor; β-Adrenoceptor;
D O I：
10.1016/0169-328X(90)90075-O
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Experiments were undertaken to examine the effect of depletion of adrenal steroids on neurotransmitter-stimulated cAMP accumulation in rat cerebral cortex slices. Long-term depletion due to bilateral adrenalectomy (ADX) and short term depletion due to the steroid synthesis inhibitor metopirone (MET) caused a significant increase in α1-adrenoceptor-mediated potentiation of β-adrenoceptor-stimulated cAMP accumulation. The effect of MET was prevented by corticosterone treatment. This effect of ADX was selective in that there was no change in α1-adrenoceptor-mediated inositol phosphate accumulation. In addition, ADX had no effect on potentiation of isoprenaline-stimulated cAMP by either the GABAB agonist baclofen or the phorbol ester, 4β-phorbol dibutyrate. However, 2-chloroadenosine-stimulated cAMP accumulation was significantly reduced in ADX rats. © 1990.
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页码：69 / 74
页数：6
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