EFFECTS OF ACETATE AND OF PYRUVATE ON PATHWAYS OF GLUCOSE CATABOLISM IN LACTATING MAMMARY TISSUE .2. SHEEP TISSUE

被引:4
作者
SMITH, RW
GLASCOCK, RF
机构
[1] National Institute for Research, Shinfield
关键词
D O I
10.1017/S002202990001298X
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
A study was made of the changes in the rates of oxidation of the C(1), C(2) and C(6) atoms of glucose and in the pathways of glucose catabolism in sheep udder tissue in vitro which occurred when acetate and pyruvate were added. Whereas in rat mammary tissue the rate of oxidation of the C(1) atom of glucose was very much greater than that of the C(6) atom, the ratio of the rates of oxidation of these 2 atoms in sheep tissue was less than 2 when glucose was the only substrate. The addition of acetate resulted in an unequal stimulation of the oxidation of these 2 atoms, with the result that the ratio of their rates of oxidation was about doubled. The rate of oxidation of the C(2) atom was also increased. Acetate also increased the participation of the pentose phosphate pathway in glucose catabolism as measured by the incorporation of the C(1) and C(6) atoms of glucose into fatty acids, lactic acid and glycerol. Pyruvate produced little effect on the rate of oxidation of the C(1) atom but somewhat depressed that of the C(6) atom of glucose. At the same time, it caused a large increase in the participation of the pentose phosphate pathway. These results are discussed with reference to re-cycling of glucose carbon in the pentose phosphate pathway and to the relationship between that pathway and fatty acid synthesis. It is noted that the incorporation of glucose carbon into the 3 intermediates used gave values for the participation of that pathway which were in better agreement than was obtained in rat tissue. It is concluded that triose phosphates are more nearly in equilibrium in sheep than in rat mammary tissue. © 1969, Proprietors of Journal of Dairy Research. All rights reserved.
引用
收藏
页码:469 / +
页数:1
相关论文
共 50 条
[41]   METABOLISM OF NEOPLASTIC TISSUE .9. ISOTOPE TRACER STUDY OF GLUCOSE CATABOLISM PATHWAYS IN NORMAL AND NEOPLASTIC TISSUES [J].
WENNER, CE ;
WEINHOUSE, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1956, 222 (01) :399-414
[42]   EXERCISE AND THE CAMP SYSTEM IN RAT ADIPOSE-TISSUE .2. NUCLEOTIDE CATABOLISM [J].
PALMER, WK ;
KALINA, CA ;
STUDNEY, TA ;
OSCAI, LB .
JOURNAL OF APPLIED PHYSIOLOGY, 1981, 50 (02) :255-258
[43]   THE EFFECTS OF DUODENAL GLUCOSE AND DEXTRIN INFUSION ON ADIPOSE-TISSUE METABOLISM IN SHEEP [J].
PEARCE, J ;
PIPEROVA, LS .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1984, 78 (03) :565-567
[44]   Effects of food restriction on the responses of the mammary gland and adipose tissue to prolactin and growth hormone in the lactating rat [J].
Flint, DJ ;
Vernon, RG .
JOURNAL OF ENDOCRINOLOGY, 1998, 156 (02) :299-305
[45]   ADRENALECTOMY AND REPLACEMENT THERAPY IN LACTATING RATS .4. EFFECT OF DEOXYCORTICOSTERONE ACETATE ON THE WATER CONTENT OF MAMMARY TISSUE AFTER ADRENALECTOMY [J].
FOLLEY, SJ ;
GREENBAUM, AL .
JOURNAL OF ENDOCRINOLOGY, 1948, 5 (1-6) :236-242
[46]   EXPRESSION OF PK-A CATALYTIC AND REGULATORY SUBUNITS IN LACTATING RAT MAMMARY TISSUE - EFFECTS OF LITTER REMOVAL [J].
GARDNER, RA ;
TRAVERS, MT ;
BARBER, MC ;
MILLER, WR ;
CLEGG, RA .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1995, 23 (03) :S452-S452
[47]   Responses of glucose metabolism to insulin in perfused mammary tissue of lactating rats: Influence of dietary history and recent insulin experience [J].
Calvert, DT ;
Clegg, RA .
EXPERIMENTAL PHYSIOLOGY, 1996, 81 (01) :131-140
[48]   METABOLIC-ACTIVITY OF BOVINE EPIDIDYMIS .2. UTILIZATION OF ACETATE, SUCCINATE, PYRUVATE, LACTATE AND GLUCOSE [J].
TURNER, TT ;
JOHNSON, AD .
JOURNAL OF REPRODUCTION AND FERTILITY, 1973, 35 (03) :445-451
[49]   VOLUNTARY INTAKE OF SILAGE BY SHEEP .2. EFFECTS OF ACETATE ON SILAGE INTAKE [J].
HUTCHINSON, KJ ;
WILKINS, RJ .
JOURNAL OF AGRICULTURAL SCIENCE, 1971, 77 (DEC) :539-+
[50]   HYPOPHYSECTOMY AND METABOLISM OF ADIPOSE TISSUE IN VITRO .2. GLUCOSE OXIDATION [J].
RENAULD, A ;
RUIZ, DC ;
FOGLIA, VG .
ACTA PHYSIOLOGICA LATINOAMERICANA, 1966, 16 (01) :95-+