MOLECULAR DESIGN OF NOVEL PGI(2) AGONISTS WITHOUT PG SKELETON .4.

被引：15
|
作者：
HAMANAKA, N
TAKAHASHI, K
NAGAO, Y
TORISU, K
TOKUMOTO, H
KONDO, K
机构：
[1] Minase Research Institute, Ono Pharmaceutical Co., Ltd. Shimamoto, Mishima, Osaka
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 10期
关键词：
D O I：
10.1016/0960-894X(95)00170-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and biological evaluation of a novel series of di or tetrahydronaphthalene-5-oxyacetic acid derivatives with the 4-benzhydryl pyrazole group is described. Among these compounds, 7 has been identified as a highly potent PGI(2) agonist with an exceptionally long in vivo duration of action.
引用
收藏
页码：1083 / 1086
页数：4
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