Mechanisms of antimicrobial peptides as characterized by solid-state NMR

被引：0
|
作者：
Rong Han [1 ,2 ]
Shenlin Wang [1 ,2 ,3 ]
机构：
[1] College of Chemistry and Molecular Engineering and Beijing NMR Center, Peking University
[2] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
[3] Beijing National Laboratory for Molecular Science
来源：
Magnetic Resonance Letters | 2022年 / 2卷 / 02期
基金：
中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
R445.2 [核磁共振成像];
学科分类号：
摘要：
Antimicrobial peptides(AMP) are small proteins that play critical roles in host defense against microbe invasion. Many AMPs disrupt the cellular membrane of microbe, while the mechanism of action of AMPs can be very sophisticated. Solid-state NMR(SSNMR) technique is powerful in characterizing the mechanism of AMPs in vivo and in vitro. This review summarizes the recent advance of SSNMR technique in AMP mechanisms characterization.We highlight the sample preparation approaches, the SSNMR spectroscopic methods, and a number of outstanding examples of AMP mechanisms elucidated via SSNMR spectroscopy.
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页码：119 / 129
页数：11
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