Mechanisms of antimicrobial peptides as characterized by solid-state NMR

被引：0
|
作者：
Rong Han [1 ,2 ]
Shenlin Wang [1 ,2 ,3 ]
机构：
[1] College of Chemistry and Molecular Engineering and Beijing NMR Center, Peking University
[2] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
[3] Beijing National Laboratory for Molecular Science
来源：
Magnetic Resonance Letters | 2022年 / 2卷 / 02期
基金：
中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
R445.2 [核磁共振成像];
学科分类号：
摘要：
Antimicrobial peptides(AMP) are small proteins that play critical roles in host defense against microbe invasion. Many AMPs disrupt the cellular membrane of microbe, while the mechanism of action of AMPs can be very sophisticated. Solid-state NMR(SSNMR) technique is powerful in characterizing the mechanism of AMPs in vivo and in vitro. This review summarizes the recent advance of SSNMR technique in AMP mechanisms characterization.We highlight the sample preparation approaches, the SSNMR spectroscopic methods, and a number of outstanding examples of AMP mechanisms elucidated via SSNMR spectroscopy.
引用
收藏
页码：119 / 129
页数：11
相关论文
共 50 条
  • [1] Mechanisms of antimicrobial peptides as characterized by solid-state NMR
    Han, Rong
    Wang, Shenlin
    MAGNETIC RESONANCE LETTERS, 2022, 2 (02) : 119 - 129
  • [2] In-cell Solid-State NMR Studies of Antimicrobial Peptides
    Separovic, Frances
    Keizer, David W.
    Sani, Marc-Antoine
    FRONTIERS IN MEDICAL TECHNOLOGY, 2020, 2
  • [3] Solid-state NMR studies of antimicrobial peptides from arachnid venoms
    Nomura, K.
    Villegas, E.
    Corzo, G.
    BIOMEDICAL SPECTROSCOPY AND IMAGING, 2014, 3 (02) : 107 - 120
  • [4] Solid-state NMR investigations of antimicrobial and cell-penetrating peptides
    Yin, Daniel
    Thompson, Sam
    Judge, Peter J.
    Watts, Anthony
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
  • [5] Solid-state NMR study of live bacteria in the presence of antimicrobial peptides
    Sani, M-A.
    Overall, S.
    Separovic, F.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2017, 46 : S390 - S390
  • [6] The membrane interactions of antimicrobial peptides revealed by solid-state NMR spectroscopy
    Bechinger, Burkhard
    Salnikov, Evgeniy S.
    CHEMISTRY AND PHYSICS OF LIPIDS, 2012, 165 (03) : 282 - 301
  • [7] SOLID-STATE NMR OF PEPTIDES AND PROTEINS
    OPELLA, SJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 8 - PHYS
  • [8] Structure and membrane interactions of antimicrobial peptides as viewed by solid-state NMR spectroscopy
    Ouellet, Marise
    Auger, Michele
    ANNUAL REPORTS ON NMR SPECTROSCOPY, VOL 63, 2008, 63 : 1 - 21
  • [9] Role of non-lamellar phases in lipid bilayers by pore-forming antimicrobial peptides as characterized by solid-state NMR methods
    Hallock, KJ
    Henzler, KA
    Santos, JS
    Lee, DK
    Omnaas, J
    Mosberg, H
    Ramamoorthy, A
    BIOPHYSICAL JOURNAL, 2000, 78 (01) : 175A - 175A
  • [10] Solid-state NMR study of antimicrobial peptides from Australian frogs in phospholipid membranes
    M. S. Balla
    J. H. Bowie
    F. Separovic
    European Biophysics Journal, 2004, 33 : 109 - 116
12345