DLC1基因在胃癌中的研究进展

被引:0
|
作者
陈航 [1 ,2 ]
黄兴茂 [1 ,2 ]
俞鹏飞 [2 ]
机构
[1] 温州医科大学研究生培养基地(浙江省肿瘤医院)
[2] 不详
基金
浙江省自然科学基金;
关键词
胃癌; DLC1基因; 治疗靶点;
D O I
暂无
中图分类号
R735.2 [胃肿瘤];
学科分类号
摘要
胃癌是全球最常见的消化道肿瘤之一,大部分患者确诊时已是进展期或晚期,化疗等常规治疗疗效较差,亟需挖掘新的有效治疗靶点以及生物标志物。DLC1是一种公认的抑癌基因,对消化系统肿瘤的发生发展起着抑制作用,其在肝癌、胃癌、结直肠癌和食管癌等多种实体肿瘤中呈现低表达状态。DLC1不仅与表观遗传修饰、细胞自噬、微生物感染以及微卫星不稳定状态密切相关,且对胃癌发生发展、治疗疗效及患者预后均具有重要影响。本文对DLC1的结构、功能及其在胃癌发生发展和治疗中的作用进行综述,以期为其后续研究提供参考。
引用
收藏
页码:143 / 147
页数:5
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