FABP4和FABP5在肿瘤免疫调控中的研究进展

被引:0
|
作者
柳周
孙圣荣
机构
[1] 武汉大学人民医院乳腺甲状腺外科
关键词
肥胖; 肿瘤; 免疫; 脂肪酸结合蛋白;
D O I
10.14188/j.1671-8852.2022.0849
中图分类号
R730.3 [肿瘤免疫学与血清学];
学科分类号
摘要
肥胖是肿瘤发展的危险因素,与多种肿瘤的不良预后有关,脂代谢紊乱成为探索肥胖症和肿瘤疾病内在联系的关键。脂肪酸结合蛋白(FABPs)是一系列水溶性小蛋白质,主要负责长链脂肪酸的转运和代谢,同时也可以作为转录因子在细胞核内发挥作用。脂肪组织来源的脂肪酸结合蛋白主要包括FABP4和FABP5,它们被鉴定为多种恶性肿瘤的致癌基因。本文总结了FABP4和FABP5在肿瘤疾病发生发展中的作用,重点介绍了FABP4和FABP5对肿瘤免疫微环境的调控机制,阐述了以FABP4和FABP5为治疗靶点的最新研究进展。
引用
收藏
页码:121 / 126
页数:6
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