Naringin ameliorates H2O2-induced oxidative damage in cells and prolongs the lifespan of female Drosophila melanogaster via the insulin signaling pathway

被引：0

作者：

Xiaomei Du ^{[1
]}

Kexin Wang ^{[1
]}

Xiaoyan Sang ^{[1
]}

Xiangxing Meng ^{[1
]}

Jiao Xie ^{[2
]}

Tianxin Wang ^{[1
]}

Xiaozhi Liu ^{[3
,4
]}

Qun Huang ^{[2
]}

Nan Zhang ^{[1
]}

Hao Wang ^{[1
]}

机构：

[1] State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology

[2] The key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University

[3] Department of neurosurgery, the Fifth Central Hospital of Tianjin

[4] Tianjin Key Laboratory of Epigenetics for Organ Department in Preterm Infants, the Fifth Central Hospital of Tianjin

来源：

Food Science and Human Wellness | 2024年 / 13卷 / 03期

关键词：

D O I：

暂无

中图分类号：

TS201.4 [食品营养学];

学科分类号：

083201 ;

摘要：

Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC 12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms.The results showed that naringin inhibited H2O2-induced decline in cell viability and decreased,the content of reactive oxygen species in cells.Meanwhile,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde content.Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells.Moreover,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of lysosomes.Furthermore,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS) pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.

引用

页码：1231 / 1245

页数：15

共 51 条

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