Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis

被引：0

作者：

Wang Liao ^{[1
]}

Jiana Wei ^{[1
,2
]}

Chongxu Liu ^{[1
]}

Haoyu Luo ^{[1
]}

Yuting Ruan ^{[3
]}

Yingren Mai ^{[1
]}

Qun Yu ^{[4
]}

Zhiyu Cao ^{[4
]}

Jiaxin Xu ^{[4
]}

Dong Zheng ^{[5
]}

Zonghai Sheng ^{[6
]}

Xianju Zhou ^{[2
]}

Jun Liu ^{[1
]}

机构：

[1] Department of Neurology,The Second Affiliated Hospital of Guangzhou Medical University

[2] Special Medical Service Center,Neuroscience Center,Integrated Hospital of Traditional Chinese Medicine,Southern Medical University

[3] Department of Rehabilitation,The Second Affiliated Hospital,Guangzhou Medical University

[4] Department of Neurology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University

[5] Department of Neurology,The Affiliated Brain Hospital of Guangzhou Medical University

[6] Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences

来源：

Neural Regeneration Research | 2024年 / 10期

基金：

中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer’s disease. Magnesium-L-threonate has recently been found to have protective effects on learning and memory in aged and Alzheimer’s disease model mice. However, the effects of magnesium-L-threonate on the gut microbiota in Alzheimer’s disease remain unknown. Previously, we reported that magnesium-L-threonate treatment improved cognition and reduced oxidative stress and inflammation in a double-transgenic line of Alzheimer’s disease model mice expressing the amyloid-β precursor protein and mutant human presenilin 1(APP/PS1). Here, we performed 16S r RNA amplicon sequencing and liquid chromatography-mass spectrometry to analyze changes in the microbiome and serum metabolome following magnesium-Lthreonate exposure in a similar mouse model. Magnesium-L-threonate modulated the abundance of three genera in the gut microbiota, decreasing Allobaculum and increasing Bifidobacterium and Turicibacter. We also found that differential metabolites in the magnesiumL-threonate-regulated serum were enriched in various pathways associated with neurodegenerative diseases. The western blotting detection on intestinal tight junction proteins(zona occludens 1, occludin, and claudin-5) showed that magnesium-L-threonate repaired the intestinal barrier dysfunction of APP/PS1 mice. These findings suggest that magnesium-L-threonate may reduce the clinical manifestations of Alzheimer’s disease through the microbiota-gut-brain axis in model mice, providing an experimental basis for the clinical treatment of Alzheimer’s disease.

引用

页码：2281 / 2289

页数：9