Multiple target drug cocktail design for attacking the core network markers of four cancers using ligand-based and structure-based virtual screening methods
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作者:
Yung-Hao Wong
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机构:National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
Yung-Hao Wong
Chih-Lung Lin
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机构:National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
Chih-Lung Lin
Ting-Shou Chen
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机构:National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
Ting-Shou Chen
Chien-An Chen
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机构:National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
Chien-An Chen
Pei-Shin Jiang
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机构:National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
Pei-Shin Jiang
Yi-Hua Lai
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机构:National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
Yi-Hua Lai
Lichieh Julie Chu
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机构:National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
Lichieh Julie Chu
Cheng-Wei Li
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机构:National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
Cheng-Wei Li
Jeremy JW Chen
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机构:National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
Jeremy JW Chen
Bor-Sen Chen
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机构:National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
Bor-Sen Chen
机构:
[1] National Tsing Hua University,Laboratory of Control and Systems Biology, Department of Electrical Engineering
[2] Industrial Technology Research Institute,Biomedical Technology and Device Research Laboratories
[3] National Chung Hsing University,Institute of Biomedical Science
[4] Chang Gung University,Molecular Medicine Research Center
来源:
BMC Medical Genomics
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8卷
关键词:
Multiple drug targets;
core network marker;
ligand-based CADD;
structure-based CADD;
virtual screening;
pharmacophore;
systems biology;
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Struct Biol Div, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Struct Biol Div, Parkville, Vic 3050, Australia
Branson, KM
Smith, BJ
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Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Struct Biol Div, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Struct Biol Div, Parkville, Vic 3050, Australia
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Res Ctr Drug Discovery, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Res Ctr Drug Discovery, Guangzhou 510006, Guangdong, Peoples R China
Yu, Miao
Gu, Qiong
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Sun Yat Sen Univ, Sch Pharmaceut Sci, Res Ctr Drug Discovery, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Res Ctr Drug Discovery, Guangzhou 510006, Guangdong, Peoples R China
Gu, Qiong
Xu, Jun
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Sun Yat Sen Univ, Sch Pharmaceut Sci, Res Ctr Drug Discovery, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Res Ctr Drug Discovery, Guangzhou 510006, Guangdong, Peoples R China
机构:
Univ Roma La Sapienza, Dept Phys, I-00185 Rome, ItalyUniv Roma La Sapienza, Dept Phys, I-00185 Rome, Italy
Caroli, Antonia
Ballante, Flavio
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机构:
Univ Roma La Sapienza, Rome Ctr Mol Design, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, ItalyUniv Roma La Sapienza, Dept Phys, I-00185 Rome, Italy
Ballante, Flavio
Wickersham, Richard B., III
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机构:
Univ Roma La Sapienza, Rome Ctr Mol Design, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, Italy
Washington Univ, Dept Biochem & Mol Biophys, Sch Med, St Louis, MO 63110 USAUniv Roma La Sapienza, Dept Phys, I-00185 Rome, Italy
Wickersham, Richard B., III
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机构:
Corelli, Federico
Ragno, Rino
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机构:
Univ Roma La Sapienza, Rome Ctr Mol Design, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, ItalyUniv Roma La Sapienza, Dept Phys, I-00185 Rome, Italy