The role of microglia in neuropsychiatric disorders and suicide

被引：0

作者：

Ralf Brisch

Szymon Wojtylak

Arthur Saniotis

Johann Steiner

Tomasz Gos

Jaliya Kumaratilake

Maciej Henneberg

Rainer Wolf

机构：

[1] Medical University of Gdańsk,Department of Forensic Medicine

[2] Medical University of Gdańsk,Department of Pathomorphology

[3] Polish Academy of Sciences,Department of Anthropology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy

[4] Knowledge University,Department of Pharmacy

[5] Otto-von-Guericke-University,Department of Psychiatry and Psychotherapy

[6] The University of Adelaide,Biological Anthropology and Comparative Anatomy Research Unit, Medical School

[7] University of Zurich,Institute of Evolutionary Medicine

[8] Hochschule Fulda,Department of Nursing and Health

[9] University of Applied Sciences,undefined

来源：

European Archives of Psychiatry and Clinical Neuroscience | 2022年 / 272卷

关键词：

Microglia; Schizophrenia; Major depressive disorder; Bipolar disorder; Affective disorders; Suicide; Dorsal raphe nucleus; Serotonin; Evolution of human lineage;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This narrative review examines the possible role of microglial cells, first, in neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research on the interactions between microglia, astrocytes and neurons and their involvement in pathophysiological processes of neuropsychiatric disorders is presented. This review focuses on results from postmortem, positron emission tomography (PET) imaging studies, and animal models of schizophrenia and depression. Third, the effects of antipsychotic and antidepressant drug therapy, and of electroconvulsive therapy on microglial cells are explored and the upcoming development of therapeutic drugs targeting microglia is described. Finally, there is a discussion on the role of microglia in the evolutionary progression of human lineage. This view may contribute to a new understanding of neuropsychiatric disorders.

引用

页码：929 / 945

页数：16

共 1151 条

[1]

Mosser CA(2017)Microglia in CNS development: Shaping the brain for the future Prog Neurobiol 149–150 1-20

[2]

Baptista S(2010)Glia: the many ways to modulate synaptic plasticity Neurochem Int 57 440-445

[3]

Arnoux I(2009)Role of microglia in neuronal degeneration and regeneration Semin Immunpathol 31 513-525

[4]

Audinat E(2009)Microglial clearance function in health and disease Neuroscience 158 1030-1038

[5]

Ben Achour SB(2014)Role of microglial M1/M2 polarisation in relapse and remission of psychiatric disorders and diseases Pharmaceuticals 7 1028-1048

[6]

Pascual O(2014)The role of pro-inflammatory cytokines in the neuro-transmission and neurogenesis in schizophrenia Prog Neuro-Psychopharmacol Biol Psychiatry 48 277-286

[7]

Walter L(2015)Neuroinflammation and depression: microglia activation, extravesicular microvesicles and microRNA dysregulation Front Cell Neurosci 9 476-506

[8]

Neumann H(2015)Astrocyte and microglial control of glutamatergic signaling: A primer on understanding the disruptive role of chronic stress J Neuroendocrin 27 498-321

[9]

Napoli I(2017)Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization Transl Psychiatry 7 e1024-665

[10]

Neumann H(2015)A starring role for microglia in brain sex differences Neuroscientist 21 306-702

← 1 2 3 4 5 6 7 8 9 10 →