Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

被引:0
作者
Amand F. Schmidt
Michael V. Holmes
David Preiss
Daniel I. Swerdlow
Spiros Denaxas
Ghazaleh Fatemifar
Rupert Faraway
Chris Finan
Dennis Valentine
Zammy Fairhurst-Hunter
Fernando Pires Hartwig
Bernardo Lessa Horta
Elina Hypponen
Christine Power
Max Moldovan
Erik van Iperen
Kees Hovingh
Ilja Demuth
Kristina Norman
Elisabeth Steinhagen-Thiessen
Juri Demuth
Lars Bertram
Christina M. Lill
Stefan Coassin
Johann Willeit
Stefan Kiechl
Karin Willeit
Dan Mason
John Wright
Richard Morris
Goya Wanamethee
Peter Whincup
Yoav Ben-Shlomo
Stela McLachlan
Jackie F. Price
Mika Kivimaki
Catherine Welch
Adelaida Sanchez-Galvez
Pedro Marques-Vidal
Andrew Nicolaides
Andrie G. Panayiotou
N. Charlotte Onland-Moret
Yvonne T. van der Schouw
Giuseppe Matullo
Giovanni Fiorito
Simonetta Guarrera
Carlotta Sacerdote
Nicholas J. Wareham
Claudia Langenberg
Robert A. Scott
机构
[1] University College London,Institute of Cardiovascular Science
[2] University Medical Center Utrecht,Department of Cardiology, Division Heart & Lungs
[3] Utrecht University,Medical Research Council Population Health Research Unit, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health
[4] UCL’s BHF Research Accelerator Centre,Department of Medicine
[5] University of Oxford,Health Data Research UK
[6] Imperial College London,Institute of Health Informatics
[7] University College London,Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health
[8] University College London,Postgraduate Program in Epidemiology
[9] The Alan Turing Institute,Centre for Population Health Research, Sansom Institute for Health Research
[10] British Library,Department of Clinical Epidemiology, Biostatistics And Bioinformatics
[11] University College London,Department of vascular medicine
[12] Farr Institute of Health Informatics,Center for Lifespan Changes in Brain and Cognition (LCBC), Dept. Psychology
[13] University of Oxford,Department of Neurology
[14] Federal University of Pelotas,Department of Neurology
[15] University of South Australia,Department Primary Care & Population Health
[16] Population,Population Health Research Institute, St George’s
[17] Policy and Practice,Centre for Population Health Sciences, The Usher Institute
[18] UCL GOS Institute of Child Health,Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care
[19] South Australian Health and Medical Research Institute,Department of Medicine, Internal Medicine
[20] Durrer Center for Cardiovascular Research,Department of Vascular Surgery
[21] Netherlands Heart Institute,Department of Surgery, Nicosia Medical School
[22] Academic Medical Center Amsterdam,Cyprus International Institute for Environmental and Public Health
[23] Academic Medical Center Amsterdam,Julius Center for Health Sciences and Primary Care
[24] Charité – Universitätsmedizin Berlin,Department of Medical Sciences
[25] corporate member of Freie Universität Berlin,MRC Epidemiology Unit
[26] Humboldt-Universität zu Berlin,Department of Epidemiology and Population Studies
[27] and Berlin Institute of Health,Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences
[28] Lipid Clinic at the Interdisciplinary Metabolism Center,Department of Clinical Medicine, Faculty of Health and Medical Sciences
[29] Charité - Universitätsmedizin Berlin,Centre for Cardiovascular Genetics, Department of Medicine
[30] BCRT - Berlin Institute of Health Center for Regenerative Therapies,Department of Medicine, Department of Pharmacology, Department of Biomedical Informatics
[31] Institute of Nutritional Science,Department of Genetics
[32] University of Potsdam,Department of Cardiology
[33] Geriatrics Research Group,Department of Epidemiology
[34] Charité - Universitätsmedizin Berlin,Department of Clinical Epidemiology
[35] Department of Nutrition and Gerontology,Department of Medical Sciences, Molecular Epidemiology
[36] German Institute of Human Nutrition Potsdam-Rehbruecke,Department of Medicine, Division of Cardiovascular Medicine
[37] E.CA Economics GmbH,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory
[38] Lübeck Interdisciplinary Platform for Genome Analytics (LIGA),Department of Epidemiology
[39] Institutes of Neurogenetics & Cardiogenetics,Department of Epidemiology and Biostatistics
[40] University of Lübeck,Institute for Community Medicine
[41] University of Oslo,Department of Internal Medicine B
[42] Genetic and Molecular Epidemiology Group,Department of Internal Medicine A
[43] Lübeck Interdisciplinary Platform for Genome Analytics (LIGA),Interfaculty Institute of Genetics and Functional Genomics
[44] Institutes of Neurogenetics & Cardiogenetics,Institute of Health and Wellbeing
[45] University of Lübeck,Department of Non
[46] Institute of Human Genetics,Communicable Disease Epidemiology
[47] Ageing Epidemiology Research Unit,The Department of Medical Research
[48] School of Public Health,Division of Pharmacoepidemiology and Clinical Pharmacology
[49] Imperial College,Department of Respiratory Medicine
[50] Institute of Genetic Epidemiology,Robertson Centre for Biostatistics
来源
BMC Cardiovascular Disorders | / 19卷
关键词
Genetic association studies; Mendelian randomisation; LDL-cholesterol; Phenome-wide association scan;
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