Remyelination properties of human embryonic nerve cells in the course of long-term cultivation

被引：0
|
作者：
V. I. Tsymbaluk
I. G. Vasilyeva
N. P. Olexenko
N. G. Chopic
O. I. Tsyubko
O. S. Galanta
机构：
[1] Ukraine Academy of Medical Sciences,A. P. Romodanov Institute of Neurosurgery
来源：
Cytology and Genetics | 2009年 / 43卷
关键词：
Mature Oligodendrocyte; Myelin Membrane; Active Precursor; Embryonic Nerve Cell; Experimental Demyelination;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied the mitogenic and differentiation potential and the remyelination properties of human embryonic nerve cells in culture. After 1 month of cultivation without differentiation agents, a 3.6-fold increase in the number of CNP-positive cells (the mitotically active precursors of oligodendrocytes) was observed. At the same time, the number of GalC-positive cells (mature oligodendrocytes) remained low. The remyelination properties of embryonic nerve cells can thus be explained by a high density of oligodendrocyte precursors. After cultivation, the population of cells maintained and enhanced their remyelination potential by increasing the number of CNP-positive cells under conditions of experimental demyelination.
引用
收藏
页码：406 / 410
页数：4
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