Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32

被引：0
|
作者：
Xiangcheng Zhu
Yanwen Duan
Zhaomeng Cui
Zhen Wang
Zengxia Li
Yun Zhang
Jianhua Ju
Hongbo Huang
机构：
[1] Xiangya International Academy of Translational Medicine,Department of Biochemistry and Molecular Biology
[2] Central South University,undefined
[3] National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery,undefined
[4] Key Laboratory of Metabolism and Molecular Medicine,undefined
[5] the Ministry of Education,undefined
[6] School of Basic Medical Sciences,undefined
[7] Fudan University,undefined
[8] CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,undefined
[9] Guangdong Key Laboratory of Marine Materia Medica,undefined
[10] South China Sea Institute of Oceanology,undefined
[11] Chinese Academy of Sciences,undefined
来源：
The Journal of Antibiotics | 2017年 / 70卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two new rearranged linear angucycline glycosides, designated grincamycins G and H (1 and 2), together with three known congers P-1894B (vineomycin A1, 3), saquayamycin B (4) and vineomycin B2 (5), were obtained from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of 1 and 2 were elucidated by MS, 1D and 2D NMR techniques. Compounds 2–5 showed significant inhibitory effect on Jurkat T-cell proliferation with IC50 values of 3.0, 0.011, 0.037 and 0.3 μM, respectively.
引用
收藏
页码：819 / 822
页数：3
相关论文
共 41 条
  • [21] Kumemicinones A-G, Cytotoxic Angucyclinones from a Deep Sea-Derived Actinomycete of the Genus Actinomadura
    Zhang, Zhiwei
    In, Yasuko
    Fukaya, Keisuke
    Yang, Taehui
    Harunari, Enjuro
    Urabe, Daisuke
    Imada, Chiaki
    Oku, Naoya
    Igarashi, Yasuhiro
    JOURNAL OF NATURAL PRODUCTS, 2022, 85 (04): : 1098 - 1108
  • [22] Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria
    Song, Yongxiang
    Li, Qinglian
    Liu, Xue
    Chen, Yuchan
    Zhang, Yun
    Sun, Aijun
    Zhang, Weimin
    Zhang, Jingren
    Ju, Jianhua
    JOURNAL OF NATURAL PRODUCTS, 2014, 77 (08): : 1937 - 1941
  • [23] Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities
    Yongxiang Song
    Jiafan Yang
    Jianchen Yu
    Jie Li
    Jie Yuan
    Nai-Kei Wong
    Jianhua Ju
    The Journal of Antibiotics, 2020, 73 : 542 - 547
  • [24] Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities
    Song, Yongxiang
    Yang, Jiafan
    Yu, Jianchen
    Li, Jie
    Yuan, Jie
    Wong, Nai-Kei
    Ju, Jianhua
    JOURNAL OF ANTIBIOTICS, 2020, 73 (08): : 542 - 547
  • [25] Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388
    Chi, Lu-Ping
    Li, Xiao-Ming
    Li, Li
    Li, Xin
    Wang, Bin-Gui
    MARINE DRUGS, 2020, 18 (03)
  • [26] Indimicins A-E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp SCSIO 03032
    Zhang, Wenjun
    Ma, Liang
    Li, Sumei
    Liu, Zhong
    Chen, Yuchan
    Zhang, Haibo
    Zhang, Guangtao
    Zhang, Qingbo
    Tian, Xinpeng
    Yuan, Chengshan
    Zhang, Si
    Zhang, Weimin
    Zhang, Changsheng
    JOURNAL OF NATURAL PRODUCTS, 2014, 77 (08): : 1887 - 1892
  • [27] Neoabyssomicins A-C, polycyclic macrolactones from the deep-sea derived Streptomyces koyangensis SCSIO 5802
    Song, Yongxiang
    Li, Qinglian
    Qin, Fengxiang
    Sun, Changli
    Liang, Hao
    Wei, Xiaoyi
    Wong, Nai-Kei
    Ye, Li
    Zhang, Yun
    Shao, Mingwei
    Ju, Jianhua
    TETRAHEDRON, 2017, 73 (36) : 5366 - 5372
  • [28] Genome-Directed Discovery of Tetrahydroisoquinolines from Deep-Sea Derived Streptomyces niveus SCSIO 3406
    Yang, Jiafan
    Song, Yongxiang
    Tang, Man-Cheng
    Li, Mingzhe
    Deng, Junwei
    Wong, Nai-Kei
    Ju, Jianhua
    JOURNAL OF ORGANIC CHEMISTRY, 2021, 86 (16): : 11107 - 11116
  • [29] Heronamides D-F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp SCSIO 03032
    Zhang, Wenjun
    Li, Sumei
    Zhu, Yiguang
    Chen, Yuchan
    Chen, Yaolong
    Zhang, Haibo
    Zhang, Guangtao
    Tian, Xinpeng
    Pan, Yu
    Zhang, Si
    Zhang, Weimin
    Zhang, Changsheng
    JOURNAL OF NATURAL PRODUCTS, 2014, 77 (02): : 388 - 391
  • [30] Chemical constituents from the deep sea-derived Streptomyces xiamenensis MCCC 1A01570 and their effects on RXRα transcriptional regulation
    Lin, Wei-Xiang
    Xie, Chun-Lan
    Zhou, Mi
    Xia, Man-Li
    Zhou, Ting-Ting
    Chen, Hai-Feng
    Yang, Xian-Wen
    Yang, Quan
    NATURAL PRODUCT RESEARCH, 2020, 34 (10) : 1461 - 1464
12345