Primary central nervous system post-transplant lymphoproliferative disorders following allogeneic hematopoietic stem cell transplantation

被引：0
作者：
Frank Lieberman
Victor Yazbeck
Anastasios Raptis
Raymond Felgar
Michael Boyiadzis
机构：
[1] University of Pittsburgh School of Medicine,Divisions of Hematology
来源：
Journal of Neuro-Oncology | 2012年 / 107卷
关键词：
Post-transplant lymphoproliferative disorders; Hematopoietic stem cell transplantation; Central nervous system; Rituximab;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). Extra nodal involvement is common in PTLD, but isolated involvement of the central nervous system (CNS) is extremely rare. Given the rarity of primary CNS-PTLD there is no consensus on optimal treatment. We report a patient who developed Epstein-Barr virus related primary CNS-PTLD following allogeneic HSCT who was treated with the monoclonal anti-CD20 antibody rituximab and reduction of immunosuppression. In addition, we review the literature and discuss treatment options for patients with primary CNS-PTLD following allogeneic HSCT.
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页码：225 / 232
页数：7
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