Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease

被引：0

作者：

Ignazio S. Piras

Christiane Bleul

Isabelle Schrauwen

Joshua Talboom

Lorida Llaci

Matthew D. De Both

Marcus A. Naymik

Glenda Halliday

Conceicao Bettencourt

Janice L. Holton

Geidy E. Serrano

Lucia I. Sue

Thomas G. Beach

Nadia Stefanova

Matthew J. Huentelman

机构：

[1] Neurogenomics Division,Present Address: Department of Neurology, Center for Statistical Genetics, Gertrude H. Sergievsky Center

[2] The Translational Genomics Research Institute,Present address: Division of Biology and Biomedical Sciences, Molecular Genetics and Genomics Program

[3] Columbia University Medical Center,Department of Neurology, Division of Neurobiology

[4] Washington University in St. Louis,undefined

[5] The University of Sydney Brain and Mind Centre and Faculty of Medicine and Health,undefined

[6] School of Medical Science,undefined

[7] and Neuroscience Research Australia,undefined

[8] Queen Square Brain Bank for Neurological Disorders and Department of Clinical and Movement Neurosciences,undefined

[9] UCL Queen Square Institute of Neurology,undefined

[10] Civin Laboratory of Neuropathology at Banner Sun Health Research Institute,undefined

[11] Medical University of Innsbruck,undefined

来源：

Acta Neuropathologica Communications | / 8卷

关键词：

Multiple system atrophy; RNA sequencing; Oligodendrocytes; Neurodegeneration;

D O I：

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学科分类号：

摘要：

Multiple system atrophy (MSA) is a rare adult-onset neurodegenerative disease of unknown cause, with no effective therapeutic options, and no cure. Limited work to date has attempted to characterize the transcriptional changes associated with the disease, which presents as either predominating parkinsonian (MSA-P) or cerebellar (MSC-C) symptoms. We report here the results of RNA expression profiling of cerebellar white matter (CWM) tissue from two independent cohorts of MSA patients (n = 66) and healthy controls (HC; n = 66). RNA samples from bulk brain tissue and from oligodendrocytes obtained by laser capture microdissection (LCM) were sequenced. Differentially expressed genes (DEGs) were obtained and were examined before and after stratifying by MSA clinical sub-type.

引用

共 398 条

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