Modulation of synaptic transmission through O-GlcNAcylation

被引：0
作者：
Seunghyo Han
Jun-Nyeong Kim
Chan Ho Park
Jin-Seok Byun
Do-Yeon Kim
Hyoung-Gon Ko
机构：
[1] Kyungpook National University,Department of Anatomy and Neurobiology, School of Dentistry, Brain Science and Engineering Institute
[2] Kyungpook National University,Department of Dental Biomaterials, School of Dentistry
[3] Kyungpook National University,Department of Oral Medicine, School of Dentistry
[4] Kyungpook National University,Department of Pharmacology, School of Dentistry
来源：
Molecular Brain | / 17卷
关键词：
O-GlcNAcylation; O-GlcNAc transferase; O-GlcNAcase; Synaptic transmission; Synaptic plasticity;
D O I：
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学科分类号：
摘要：
O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by two enzymes: O-GlcNAc transferase and O-GlcNAcase. In addition to roles in diabetes and cancer, recent pharmacological and genetic studies have revealed that O-GlcNAcylation is involved in neuronal function, specifically synaptic transmission. Global alteration of the O-GlcNAc level does not affect basal synaptic transmission while the effect on synaptic plasticity is unclear. Although synaptic proteins that are O-GlcNAcylated are gradually being discovered, the mechanism of how O-GlcNAcylated synaptic protein modulate synaptic transmission has only been reported on CREB, synapsin, and GluA2 subunit of AMPAR. Future research enabling the manipulation of O-GlcNAcylation in individual synaptic proteins should reveal hidden aspects of O-GlcNAcylated synaptic proteins as modulators of synaptic transmission.
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