Suicide risk and prevalence of major depressive disorder (MDD) among individuals infected with HIV-1 subtype C versus B in Southern Brazil

被引:0
|
作者
Sergio Monteiro de Almeida
Francisco Jaime Barbosa
Rujvi Kamat
Ana Paula de Pereira
Sonia Mara Raboni
Indianara Rotta
Clea Elisa Ribeiro
Mariana Cherner
Ronald J. Ellis
Joseph Hampton Atkinson
机构
[1] Universidade Federal do Paraná,
[2] Faculdades Pequeno Príncipe,undefined
[3] Curitiba,undefined
[4] Paraná; Instituto de Pesquisa Pelé Pequeno Príncipe,undefined
[5] Hospital de Clínicas,undefined
[6] UFPR,undefined
[7] Seção de Virologia,undefined
[8] Setor Análises Clínicas,undefined
[9] University of California,undefined
来源
Journal of NeuroVirology | 2016年 / 22卷
关键词
MDD; HIV-associated neurocognitive disorders (HAND); HIV-1; HIV-1 subtype B; HIV-1 subtype C; Efavirenz;
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中图分类号
学科分类号
摘要
Major depressive disorder (MDD) is among the most prevalent neuropsychiatric disorders associated with HIV infection; however, its risks and neurobiologic correlates in diverse cultures are poorly understood. This study aimed to examine the frequency of MDD among HIV+ participants in southern Brazil. We hypothesized that the frequency and severity of MDD would be higher among individuals with HIV+ compared with HIV− and higher in HIV subtype B compared with C. Individuals with HIV (n = 39) as well as seronegative controls (n = 22) were enrolled in a cross-sectional, prospective, observational study. Current and lifetime history of MDD was diagnosed by MINI-Plus; symptom severity was assessed by Beck Depression Inventory-II (BDI-II). Current and past episodes of MDD were significantly more frequent in the HIV+ versus HIV− group: current MDD, 15 (38.5 %) vs. 0 (0 %), p = 0.0004; past MDD, 24 (61.5 %) vs. 3 (13.6 %), p = 0.0004. The median BDI-II score in the HIV+ group was significantly higher than that in the HIV− (13 (8–27.5) vs. 2.5 (1–5.5); p < 0.0001). Current suicide risk, defined as during the last month, was found in 18 % of participants in the HIV-positive and none in the HIV-negative group. Neither current MDD frequency (8 (57.1 %) vs. 6 (40 %), p = 0.47) nor BDI-II score differed across subtypes B and C. HIV+ group may be more likely to experience current MDD than HIV−. This was the first study to compare the frequency and severity of MDD in HIV subtypes B and C; we found no difference between HIV subtypes B and C.
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页码:789 / 798
页数:9
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