Pathophysiological mechanisms of gastroesophageal reflux disease in children.

被引：16
作者：
Davidson G.P. [1 ]
Omari T.I. [1 ]
机构：
[1] Centre for Paediatric and Adolescent Gastroenterology, Women's and Children's Hospital
来源：
Current Gastroenterology Reports | 2001年 / 3卷 / 3期
关键词：
Gastric Emptying; Gastroesophageal Reflux; Lower Esophageal Sphincter; Gastroesophageal Reflux Disease; Lower Esophageal Sphincter Relaxation;
D O I：
10.1007/s11894-001-0030-7
中图分类号：
学科分类号：
摘要：
Gastroesophageal reflux (GER) is an extremely common pediatric problem, but only in the past few years have we developed a better understanding of its pathophysiology. This is related to the wider use of investigative tools such as flexible endoscopy, 24-hour pH monitoring, and more recently, micromanometric methods and noninvasive breath tests, which have been particularly useful in infants. This paper reviews our current understanding of the esophageal and gastric mechanisms contributing to the pathophysiology of GER. In this context, we also highlight areas where new therapeutic approaches may be beneficial.
引用
收藏
页码：257 / 262
页数：5
相关论文
共 164 条
[1]  
Orenstein S(1991)Gastroesophageal reflux Curr Prob Pediatr 21 193-241
[2]  
Davidson GP(2000)Reflux in children Baillieres Clin Gastroenterol 14 839-855
[3]  
Omari TI(1996)Intraluminal micromanometry: an evaluation of the dynamic performance of micro-extrusions and sleeve sensors Neurogastroenterol Motil 8 241-245
[4]  
Omari T(2000)Intraluminal impedance: an ideal technique for evaluation of pediatric gastroesophageal reflux disease Curr Gastroenterol Rep 2 259-264
[5]  
Bakewell M(1975)A rapid pull-through technique for measuring lower esophageal sphincter pressure Gastroenterology 68 437-443
[6]  
Fraser R(1976)A new technique for continuous sphincter pressure measurement Gastroenterology 70 117-123
[7]  
Tobias GW(1976)Lower esophageal sphincter function in children with and without gastroesophageal reflux Gastroenterology 71 236-241
[8]  
Skopnik H(1978)Incompetent lower esophageal sphincter and gastroesophageal reflux in recurrent pulmonary disease of infancy and childhood J Pediatr 93 23-27
[9]  
Dodds WJ(1978)Decreased lower esophageal sphincter pressure in children with symptoms of gastroesophageal reflux Am J Dis Child 132 528-529
[10]  
Hogan WJ(1980)Mechanisms of gastroesophageal reflux in children J Paediatr 97 244-249
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