Mediastinal syndrome from plasmablastic lymphoma in human immunodeficiency virus and human herpes virus 8 negative patient with polycythemia vera: a case report

被引：2

作者：

Cajozzo M. ^{[1
]}

Palumbo V.D. ^{[1
,2
]}

Buscemi S. ^{[1
]}

Damiano G. ^{[1
]}

Florena A.M. ^{[3
]}

Cabibi D. ^{[3
]}

Raffaele F. ^{[1
]}

Anzalone A.A. ^{[1
]}

Fatica F. ^{[1
]}

Cocchiara G. ^{[1
]}

Dioguardi S. ^{[1
]}

Bruno A. ^{[4
]}

Caronia F.P. ^{[5
]}

Lo Monte A.I. ^{[1
]}

机构：

[1] Department of Surgical, Oncological and Stomatological Disciplines, University of Palermo, Via Del Vespro 129, Palermo

[2] Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo

[3] Department of Science for Health Promotion and for Mother and Child “G. D’Alessandro”, University of Palermo, Palermo

[4] Department of Diagnostic Medicine and Prevention, S. Orsola-Malpighi Hospital, University of Bologna, Bologna

[5] Mediterranean Oncological Institute (IOM), Catania

来源：

Journal of Medical Case Reports | / 11卷 / 1期

关键词：

Case report; Fine-needle aspiration biopsy; Hematology; Rare clinical case; Thoracic surgery;

D O I：

10.1186/s13256-016-1183-1

中图分类号：

学科分类号：

摘要：

Background: Plasmoblastic lymphoma is a rare and aggressive subtype of diffuse large B cell lymphoma, which occurs usually in the jaw of immunocompromised subjects. Case presentation: We describe the occurrence of plasmoblastic lymphoma in the mediastinum and chest wall skin of an human immunodeficiency virus-negative 63-year-old Caucasian man who had had polycytemia vera 7 years before. At admission, the patient showed a superior vena cava syndrome, with persistent dyspnoea, cough, and distension of the jugular veins. Imaging findings showed a 9.7 × 8 × 5.7 cm mediastinal mass. A chest wall neoformation biopsy and ultrasound-guided fine-needle aspiration biopsy of the mediastinal mass allowed diagnosis of plasmoblastic lymphoma and establishment of an immediate chemotherapeutic regimen, with rapid remission of compression symptoms. Conclusions: Plasmoblastic lymphoma is a very uncommon, difficult to diagnose, and aggressive disease. The presented case represents the first rare mediastinal plasmoblastic lymphoma in a human immunodeficiency virus-/human herpesvirus-8-negative patient. Pathologists should be aware that this tumor does appear in sites other than the oral cavity. Fine-needle aspiration biopsy is a low-cost, repeatable, easy-to-perform technique, with a high diagnostic accuracy and with very low complication and mortality rates. Fine-needle aspiration biopsy could represent the right alternative to surgery in those patients affected by plasmoblastic lymphoma, being rapid and minimally invasive. It allowed establishment of prompt medical treatment with subsequent considerable reduction of the neoplastic tissue and resolution of the mediastinal syndrome. © 2017 The Author(s).

引用

共 30 条

[1] Delecluse H.J., Anagnostopoulos I., Dallenbach F., Et al., Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection, Blood, 89, pp. 1413-1420, (1997)
[2] Thirlwell C., Sarker D., Stebbing J., Bower M., Acquired immunodeficiency syndrome-related lymphoma in the era of highly active antiretroviral therapy, Clin Lymphoma, 4, pp. 86-92, (2003)
[3] Castillo J., Pantanowitz L., Dezube B.J., HIV-associated plasmablastic lymphoma: lessons learned from 112 published cases, Am J Hematol, 83, pp. 804-809, (2008)
[4] Ojanguren J., Collazos J., Martinez C., Alvarez J., Mayo J., Epstein-Barr virus-related plasmablastic lymphomas arising from long-standing sacrococcygeal cysts in immunosuppressed patients, AIDS, 17, pp. 1582-1584, (2003)
[5] Lester R., Li C.H., Phillips P., Et al., Improved outcome of human immunodeficiency virus-associated plasmablastic lymphoma of the oral cavity in the era of highly active antiretroviral therapy: a report of two cases, Leuk Lymphoma, 45, pp. 1881-1885, (2004)
[6] Panos G., Karveli E.A., Nikolatou O., Falagas M.E., Prolonged survival of an HIV-infected patient with plasmablastic lymphoma of the oral cavity, Am J Hematol, 82, pp. 761-765, (2007)
[7] Teruya-Feldstein J., Chiao E., Filippa D.A., Et al., CD20-negative large-cell lymphoma with plasmablastic features: a clinically heterogenous spectrum in both HIV-positive and -negative patients, Ann Oncol, 15, pp. 1673-1679, (2004)
[8] Papageorgiou M.V., Alexopoulou A., Kontopidou F., Filiotou A., Koskinas J., Pectasides D., Concomitant diagnosis of myeloproliferative neoplasm and non-Hodgkin’s lymphoma in a patient with portal vein thrombosis, Anticancer Res, 31, pp. 1467-1469, (2011)
[9] Swerdlow S.H., Campo E., Harris N.L., Et al., WHO classification of tumours of haematopoietic and lymphoid tissues, pp. 256-257, (2008)
[10] NCCN Practice Guidelines in Oncology, AIDS-related B-cell lymphomas (AIDS-2, (2010)

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