OnabotulinumtoxinA (BOTOX®)A Review of its Use in the Prophylaxis of Headaches in Adults with Chronic Migraine

被引：0
|
作者：
James E. Frampton
机构：
[1] Adis,
来源：
Drugs | 2012年 / 72卷
关键词：
Migraine; Topiramate; Chronic Migraine; Medication Overuse; OnabotulinumtoxinA;
D O I：
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学科分类号：
摘要：
This article reviews the pharmacology, therapeutic efficacy and tolerability profile of intramuscularly injected onabotulinumtoxinA (onaBoNTA; BOTOX®) for headache prophylaxis in adults with chronic migraine, with a focus on UK labelling for the drug. The pharmacological actions of onaBoNTA include a direct antinociceptive (analgesic) effect; while not fully understood, the mechanism of action underlying its headache prophylaxis effect in chronic migraine is presumed to involve inhibition of peripheral and central sensitization in trigemino-vascular neurones.
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页码：825 / 845
页数：20
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