Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

[1] Oakley H(2006)Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation J Neurosci 26 10129-10140

[2] Cole SL(2002)The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 353-356

[3] Logan S(2011)Dynamic analysis of amyloid beta-protein in behaving mice reveals opposing changes in ISF versus parenchymal Abeta during age-related plaque formation J Neurosci 31 15861-15869

[4] Maus E(2012)Biochemistry of amyloid beta-protein and amyloid deposits in Alzheimer disease Cold Spring Harb Perspect Biol Med 2 a006262-3277

[5] Shao P(2012)Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction Cold Spring Harb Perspect Biol Med 2 a006338-235

[6] Craft J(2013)Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein Biochemistry 52 3264-190

[7] Guillozet-Bongaarts A(2009)Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model Neurobiol Dis 33 229-796

[8] Ohno M(2013)Area-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer's disease: dissociation between somatosensory cortex and hippocampus PLoS One 8 e74667-643

[9] Disterhoft J(2010)Sex- and brain region-specific acceleration of beta-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease Mol Brain 3 34-2283

[10] Van Eldik L(2010)Phospho-eIF2alpha level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice PLoS One 5 e12974-292

[1] Oakley H(2006)Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation J Neurosci 26 10129-10140

[2] Cole SL(2002)The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 353-356

[3] Logan S(2011)Dynamic analysis of amyloid beta-protein in behaving mice reveals opposing changes in ISF versus parenchymal Abeta during age-related plaque formation J Neurosci 31 15861-15869

[4] Maus E(2012)Biochemistry of amyloid beta-protein and amyloid deposits in Alzheimer disease Cold Spring Harb Perspect Biol Med 2 a006262-3277

[5] Shao P(2012)Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction Cold Spring Harb Perspect Biol Med 2 a006338-235

[6] Craft J(2013)Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein Biochemistry 52 3264-190

[7] Guillozet-Bongaarts A(2009)Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model Neurobiol Dis 33 229-796

[8] Ohno M(2013)Area-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer's disease: dissociation between somatosensory cortex and hippocampus PLoS One 8 e74667-643

[9] Disterhoft J(2010)Sex- and brain region-specific acceleration of beta-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease Mol Brain 3 34-2283

[10] Van Eldik L(2010)Phospho-eIF2alpha level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice PLoS One 5 e12974-292