Therapeutic potential of cancer stem cells

被引：0
作者：
Chunguang Yang
Kunlin Jin
Yangping Tong
William Chi Cho
机构：
[1] Central South University,Department of Otorhinolaryngology, Head and Neck Surgery, Xiangya Hospital
[2] University of North Texas Health Science Center,Department of Pharmacology and Neuroscience
[3] Changsha Central Hospital,Department of Neurology
[4] Queen Elizabeth Hospital,Department of Clinical Oncology
来源：
Medical Oncology | 2015年 / 32卷
关键词：
Cancer stem cells; Signaling pathway; Therapeutics; Epithelial–mesenchymal transition;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer’s relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.
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