Potential dose-conformity advantages with multi-source intensity-modulated brachytherapy (IMBT)

被引：19

作者：

Ebert M.A. ^{[1
]}

机构：

[1] Department of Radiation Oncology, Newcastle Mater Hospital, University of Newcastle, Waratah, NSW 2310

来源：

Australasian Physical and Engineering Sciences in Medicine | 2006年 / 29卷 / 02期

关键词：

Brachytherapy; Conformity; Intensity modulation;

D O I：

10.1007/BF03178889

中图分类号：

学科分类号：

摘要：

The possibilities for optimizing brachytherapy by including additional degrees of freedom in source design were investigated. This included examining optimised dose delivery with a brachytherapy source that can provide intensity-modulated dose delivery in angle about the source travel direction (to achieve intensity-modulated brachytherapy-IMBT). A prostate HDR case was selected as an example. An inverse planning algorithm was used to define how an asymmetric radiation source can be controlled in multiple source catheters to maximize tumour dose coverage and minimize urethral and rectal doses. Substantial improvements in conformity in terms of tumour coverage and urethral dose reduction could be achieved when conventional HDR source positioning was used with IMBT. With the objective definition used in the example however, rectal doses could not be improved over those delivered via conventional HDR. When source position was included as a variable in IMBT, significant conformity improvements result for all structures. IMBT would be a technically challenging form of therapy that would be strongly influenced by the type of sources that could be created for it. This study has shown however that there is a potential for improving dose conformity with such a therapy. Introduction of IMBT techniques would require conventional brachytherapy concepts to be radically modified. Copyright © 2006 ACPSEM/EA.

引用

页码：165 / 171

页数：6

共 21 条

[1]

Sloboda R.S., Pearcey R.G., Gillan S.J., Optimized low dose rate pellet configurations for intravaginal brachytherapy, Int J Radiat Oncol Biol Phys, 26, pp. 499-511, (1993)

[2]

Kneschaurek P., Schiessl W., Wehrmann R., Volume-based dose optimisation in brachytherapy, Int J Radiat Oncol Biol Phys, 45, pp. 811-815, (1999)

[3]

Kolkman-Deurloo I.K., Visser A.G., Niel C.G., Driver N., Levendag P.C., Optimisation of interstitial volume implants, Radioth Oncol, 31, pp. 229-239, (1994)

[4]

Edmundson G.K., Yan D., Martinez A.A., Intraoperative optimisation of needle placement and dwell times for conformal prostate brachytherapy, Int J Radiat Oncol Biol Phys, 33, pp. 1257-1263, (1995)

[5]

Giannouli S., Baltas D., Milickovic N., Lahanas M., Kolotas C., Zamboglou N., Uzunoglu N., Autoactivation of source dwell positions for HDR brachytherapy treatment planning, Med Phys, 27, pp. 2517-2520, (2000)

[6]

Sadegh P., Mourtada F.A., Taylor R.H., Anderson J.H., Brachytherapy optimal planning with application to intravascular therapy, Medical Image Analysis, 3, pp. 223-236, (1999)

[7]

Lessard E., Pouliot J., Inverse planning anatomy-based optimisation for HDR-brachytherapy of the prostate using fast simulated annealing algorithm and dedicated objective function, Med Phys, 28, pp. 773-779, (2001)

[8]

Cetingoz R., Ataman O.U., Tuncel N., Sen M., Kinay M., Optimisation in high dose rate brachytherapy for utero-vaginal applications, Radioth Oncol, 58, pp. 31-36, (2001)

[9]

Messing E.M., Zhang J.B., Rubens D.J., Brasacchio R.A., Strang J.G., Soni A., Schell M.C., Okunieff P.G., Yu Y., Intraoperative optimized inverse planning for prostate brachytherapy: Early experience, Int J Radiat Oncol Biol Phys, 44, pp. 801-808, (1999)

[10]

Lachance B., Beliveau-Nadeau D., Lessard E., Chretien M., Hsu I.C., Pouliot J., Beaulieu L., Vigneault E., Early clinical experience with anatomy-based inverse planning dose optimisation for high-dose-rate boost of the prostate, Int J Radiat Oncol Biol Phys, 54, pp. 86-100, (2002)

← 1 2 3 →