Smad2 and Smad4 gene mutations in hepatocellular carcinoma

被引：0

作者：

M C Yakicier

M B Irmak

A Romano

M Kew

M Ozturk

机构：

[1] Bilkent University,Department of Molecular Biology and Genetics

[2] University of The Witwatersrand,undefined

[3] Institute of Molecular Pathology,undefined

来源：

Oncogene | 1999年 / 18卷

关键词：

hepatocellular carcinoma; Smad2; Smad4; TGFβ; tumor suppressor genes; somatic mutation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

TGF-β is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-β pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4 (Asp332Gly and Cys401Arg) and one in Smad2 (Gln407Arg) genes. All three mutations were A:T → G:C transitions suspected to result from oxidative stress as observed in mitochondrial DNA. These observation demonstrate that TGF-β pathway is altered in hepatocellular carcinoma.

引用

页码：4879 / 4883

页数：4