Synthesis and Analgesic Activity of Substituted 4-(Het)aryl-4-oxo-2-thienylaminobut-2-enoic Acids

被引：0
|
作者：
S. A. Shipilovskikh
R. R. Makhmudov
D. Yu. Lupach
P. T. Pavlov
E. V. Babushkina
A. E. Rubtsov
机构：
[1] State Higher Professional Educational Institution “Perm State National Research University”,Natural Sciences Institute
[2] Federal State Higher Professional Educational Institution “Perm State National Research University”,undefined
[3] OOO Lakton,undefined
[4] State Scientific Institution “Federal Scientific Center for Medical-Prophylactic Population Health Risk Management Technologies”,undefined
来源：
Pharmaceutical Chemistry Journal | 2013年 / 47卷
关键词：
substituted 4-aryl-4-oxo-2-thienylaminobut-2-enoic acids; synthesis; analgesic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of 4-aryl-4-oxo-2-thienylaminobut-2-enoic acids was synthesized by interaction of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids with Gewald 2-aminothiophenes. All the compounds synthesized were found to have analgesic activity at or above the levels of the reference compounds.
引用
收藏
页码：366 / 370
页数：4
相关论文
共 50 条
  • [1] SYNTHESIS AND ANALGESIC ACTIVITY OF SUBSTITUTED 4-(HET)ARYL-4-OXO-2-THIENYLAMINOBUT-2-ENOIC ACIDS
    Shipilovskikh, S. A.
    Makhmudov, R. R.
    Lupach, D. Yu.
    Pavlov, P. T.
    Babushkina, E. V.
    Rubtsov, A. E.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2013, 47 (07) : 366 - 370
  • [2] Synthesis and Antibacterial Activity of 4-Oxo-2-thienylaminobut-2-enoic Acids
    Gorbunova, I. A.
    Shadrin, V. M.
    Pulina, N. A.
    Novikova, V. V.
    Dubrovina, S. S.
    Shipilovskikh, D. A.
    Shipilovskikh, S. A.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2023, 93 (01) : 8 - 15
  • [3] Search of Antimicrobial Activity in a Series of Substituted 4-Aryl-4-oxo-2-tienilaminobut-2-enoic Acids
    Shipilovskikh, Sergei A.
    Makhmudov, R. R.
    Balandina, S. Yu
    Rubtsov, Aleksandr E.
    MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2019), 2020, 2280
  • [4] Synthesis, antimicrobial and analgesic activity of N-substituted 2-amino-4-aryl-4-oxo-2-butaneoic acids
    Koz'minykh E.N.
    Belyaev A.O.
    Koz'minykh V.O.
    Makhmudov R.R.
    Odegova T.F.
    Pharmaceutical Chemistry Journal, 2002, 36 (11) : 604 - 607
  • [5] Synthesis and biological activity of substituted 4-aryl-2-methylenehydrazino-4-oxobut-2-enoic acids and their derivatives
    N. A. Pulina
    V. V. Zalesov
    O. A. Bystritskaya
    A. E. Rubtsov
    N. V. Kutkovaya
    Pharmaceutical Chemistry Journal, 2009, 43 : 444 - 447
  • [6] Synthesis and biological activity of substituted 4-aryl-2-methylenehydrazino-4-oxobut-2-enoic acids and their derivatives
    Pulina, N. A.
    Zalesov, V. V.
    Bystritskaya, O. A.
    Rubtsov, A. E.
    Kutkovaya, N. V.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2009, 43 (08) : 444 - 447
  • [7] Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids
    Gorbunova, I. A.
    Nikonov, I. P.
    Makhmudov, R. R.
    Shipilovskikh, D. A.
    Silaichev, P. S.
    Shipilovskikh, S. A.
    RUSSIAN CHEMICAL BULLETIN, 2023, 72 (09) : 2255 - 2262
  • [8] Synthesis, antimicrobial, and analgesic activity of 4-aryl-2-tert- butylamino-4-oxo-2-butenoic acids
    Koz'minykh V.O.
    Belyaev A.O.
    Koz'minykh E.N.
    Odegova T.F.
    Makhmudov R.R.
    Pharmaceutical Chemistry Journal, 2004, 38 (11) : 602 - 604
  • [9] Synthesis, antimicrobial, and analgesic activity of 4-aryl-2-N-morpholino- 4-oxo-2-butenoic acids
    Koz'minykh V.O.
    Belyaev A.O.
    Koz'minykh E.N.
    Makhmudov R.R.
    Odegova T.F.
    Pharmaceutical Chemistry Journal, 2004, 38 (8) : 431 - 433
  • [10] SYNTHESIS, INTRAMOLECULAR CYCLIZATION AND ANTINOCICEPTIVE ACTIVITY OF 4-(HET)ARYL-2-{[3-(ETHOXYCARBONYL)-4-(4-R-PHENYL)THIOPHEN-2-YL]AMINO}4-OXOBUT-2-ENOIC ACIDS
    Nikonov, I. P.
    Sharavyeva, Yu. O.
    Makhmudov, R. R.
    Shipilovskikh, D. A.
    Gorbunova, I. A.
    IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA, 2024, 67 (11): : 22 - 32
12345