Dendritic cells and the immunopathogenesis of systemic lupus erythematosus

被引：0
作者：
Seetha Monrad
Mariana J. Kaplan
机构：
[1] University of Michigan,Division of Rheumatology
[2] 5520 MSRBI,undefined
来源：
Immunologic Research | 2007年 / 37卷
关键词：
Systemic lupus erythematosus; Autoimmunity; Dendritic cell; Interferon; Apoptosis; Toll-like receptor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Over the last decade, the role of dendritic cells (DCs) in the immunopathogenesis of systemic lupus erythematosus (SLE) has become apparent. As unique mediators of both tolerance and immunity, aberrant myeloid and plasmacytoid DC function can promote autoimmune responses via a number of mechanisms and proinflammatory pathways. This review provides an overview of DC function, the potential role of DCs in promoting autoimmune responses in SLE, and how other abnormalities in lupus can lead to an enhanced engagement of DCs in immune responses. How medications used to treat SLE and other autoimmune conditions may exert effects on DCs is also explored.
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页码：135 / 145
页数：10
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[1]  
Herrmann M(2000)Etiopathogenesis of systemic lupus erythematosus Immunol Today 21 424-426
[2]  
Voll RE(2005)T- and B-cell abnormalities in systemic lupus erythematosus Crit Rev Immunol 25 123-140
[3]  
Kalden JR(2002)The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells J Immunol 169 6020-6029
[4]  
Nagy G(2001)From T to B and back again: positive feedback in systemic autoimmune disease Nat Rev Immunol 1 147-153
[5]  
Koncz A(2005)Naive CD4+ T cells from lupus-prone Fasintact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation J Immunol 174 5100-5109
[6]  
Perl A(2003)T cell abnormalities in human and mouse lupus: intrinsic and extrinsic Curr Opin Rheumatol 15 542-547
[7]  
Kaplan MJ(2005)The expression of human leukocyte antigen-DR and CD25 on circulating T cells in cutaneous lupus erythematosus and correlation with disease activity Exp Dermatol 14 454-459
[8]  
Lewis EE(2004)Induction of costimulation of human CD4 T cells by tumor necrosis factor-related apoptosis-inducing ligand: possible role in T cell activation in systemic lupus erythematosus Arthritis Rheum 50 629-639
[9]  
Shelden EA(2004)Up-regulation of IL-18 and predominance of a Th1 immune response is a hallmark of lupus nephritis Clin Exp Immunol 138 171-178
[10]  
Shlomchik MJ(2004)Th1/Th2 cytokines in patients with systemic lupus erythematosus: is tumor necrosis factor alpha protective? Semin Arthritis Rheum 33 404-413
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