Novel imaging and related techniques for studies of diseases of the central nervous system: a review

被引：0
作者：
Zhenfeng Dai
Yi Sun
Xin Zhao
Xiaoping Pu
机构：
[1] Peking University,National Key Research Laboratory of Natural and Biomimetic Drugs
[2] Peking University,Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences
来源：
Cell and Tissue Research | 2020年 / 380卷
关键词：
Imaging technology; MALDI-TOF MSI; Tracer-based magnetic resonance imaging; CLARITY technology; Central nervous system;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Imaging technologies for the analysis of the central nervous system are rapidly developing. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging, tracer-based magnetic resonance imaging, CLARITY technology and optogenetics can be used to visualize small molecules in brain tissues, the interstitial system of the brain and neuronal circuits in whole-brain samples. These tools serve as powerful technical means to explore the mechanisms underlying disease models and to evaluate the effects of drugs. Here, we review the constituting principles of these imaging techniques and describe their applications in the field of neuroscience.
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页码：415 / 424
页数：9
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