Acute effects of L-dopa on event-related desynchronization in Parkinson's disease

被引：0

作者：

G. Magnani

M. Cursi

L. Leocani

M. A. Volonté

G. Comi

机构：

[1] Department of Clinical Neurophysiology,

[2] San Raffaele Scientific Institute,undefined

[3] Milan,undefined

[4] Italy,undefined

[5] Department of Neurology,undefined

[6] San Raffaele Scientific Institute,undefined

[7] Via Olgettina 48,undefined

[8] I-20132 Milan,undefined

[9] Italy,undefined

来源：

Neurological Sciences | 2002年 / 23卷

关键词：

Key words Event-related desynchronization; Parkinson's Disease; L-Dopa;

D O I：

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中图分类号：

学科分类号：

摘要：

We tested whether dispersible L-dopa has acute effects on event-related desynchronization (ERD) of the mu rhythm in patients with idiopathic Parkinson's disease (IPD). ERD to voluntary movement is delayed in akinetic IPD patients and improves after chronic L-dopa treatment. We evaluated ERD to self-paced finger movement in 14 IPD patients (before and 30–40 min after oral administration of dispersible L-dopa) and in 10 normal subjects. Sensorimotor ERD onset contralateral to movement was significantly delayed in IPD patients compared to normal subjects. This abnormality was no longer significant after L-dopa treatment. We conclude that a single dose of dispersible L-dopa can improve not only motor performance in IPD patients but also the timing of cortical activation of sensorimotor areas during motor programming.

引用

页码：91 / 97

页数：6