The biological and therapeutic relevance of mRNA translation in cancer

被引：0
|
作者：
Sarah P. Blagden
Anne E. Willis
机构：
[1] Imperial College Hammersmith Campus,Department of Oncology
[2] Medical Research Council Toxicology Unit,undefined
来源：
Nature Reviews Clinical Oncology | 2011年 / 8卷
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摘要：
The translation of mRNA is a tightly regulated process that is necessary for protein synthesis, and dysregulation of this process is associated with the development and progression of cancers. This Review highlights the components of translation machinery and how alterations in these proteins and their principle upstream signaling pathways can impact on cancer. Drugs that are currently being developed to target the translational machinery are also discussed.
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页码：280 / 291
页数：11
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